Assistant Professor, Center for Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain
Pilar Esteve is a permanent faculty member at the Center for Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain. She began her carrier working at the Lombardi Cancer Center (Georgetown University) in the USA and thereafter obtained her Ph.D. degree from the Autónoma University in Madrid, studying the molecular basis of tumorigenesis and apoptosis at the Instituto de Investigaciones Biomedicas (CSIC-UAM). She then moved to the Instituto Cajal, CSIC, Madrid, to follow her carrier in the field of neuroscience, addressing the molecular mechanism of vertebrate eye development. In 2010 she moved to the CBM-SO where she currently works. PE is the author of 30 publications and she has received support from national and private granting agencies. She is actively engaged in teaching neuro-developmental topics at different Master courses of the UAM, acts as a reviewer for different journals and granting agencies, and is engaged in outreach activities. Her research efforts aim at understanding the biological role of SFRP1 (Secreted Frizzled Related Protein 1), a secreted protein with a dual role in Wnt signaling and negative regulation of ADAM10, a metalloprotease involved in the proteolytical processing of a large number of substrates, including the Amyloid Precursor Protein. Focusing on the latter function she is now addressing the potential value of SFRP1 as a biomarker and therapeutic target for Alzheimer’s disease and neuroinflammatory processes at large.