October 31, 2022
October 31, 2022
Nasally administered anti-CD3 monoclonal antibody induces an anti-inflammatory immune response that attenuates neuroinflammation in the brain resident microglia and astrocytes. The mechanism of action of nasal anti-CD3 is associated with the induction of regulatory T cells (Tregs) in the cervical lymph node and the subsequent migration of these Tregs to ...
October 25, 2023
Despite evidence demonstrating that impairments in the clearance of toxic waste in the brain contribute to late-onset Alzheimer’s disease, the science of lymphatic system dysfunction and the systems regulating entry and exit through the blood-brain barrier has been largely overlooked in Alzheimer’s disease — until now. The Maxine and Richard ...
December 19, 2019
In healthy humans, the cerebrospinal fluid (CSF) is renewed approximately four times per day, and the skull is lined with membranes that protect the brain and spinal cord. More than 200 years ago, it was speculated that the brain was also protected by lymphatic vessels whose purpose is, among other ...
March 28, 2019
In healthy humans, the cerebrospinal fluid (CSF) is renewed approximately four times a day. In aging adults, impaired function of lymphatic vessels in the meninges can lead to accelerated accumulation of toxic amyloid beta protein in the brain. The meninges are made up of membranes that line the skull in ...
December 13, 2018
Blood vessels supply our organs with oxygen and nutrients. Another set of vessels, called the lymphatic vessels, perform other very important roles in the maintenance of tissues as they remove all the waste and toxic compounds the organ produces and also serve as a path for immune cells from organs ...
July 5, 2016
“The Central Nervous System (CNS) was historically considered as an immune privileged organ. Key factors contributing to immune privilege were considered to be the blood-brain barrier and the lack of lymphatic drainage of the CNS, which results in a physical disconnect with the immune system. Our lab has shattered the ...
October 7, 2022
Alzheimer’s disease (AD) is characterized by accumulation of toxic proteins (amyloid beta and tau) in the brain. Human genetics reveals that dysfunction of microglia, the brain cells responsible for clearing debris, contributes to AD progression. Microglial activity is balanced by activating and inhibiting signals to ensure efficient debris removal while ...
June 23, 2022
We built an iterative scheme of “modeling->screening->validation” through the collaboration within the AD4 consortium. More than 3,000 compounds were physically screened through automated imaging of the 3D Alzheimer’s in a Dish™ assay developed by AD4 consortium collaborators, and nearly 30 compounds have shown an ability to significantly reduce the level ...
February 17, 2022
In fiscal year 2020, we focused on identifying molecular mechanisms related to six confirmed screening hits and predicting more candidates based on such mechanisms. Specifically, our collaborators in the Tanzi lab and the Kim lab successfully confirmed six primary hits through secondary screening and toxicity tests, and we were able ...
December 21, 2020