Guojun Bu, Ph.D.

Professor of Neuroscience, Mayo Clinic Jacksonville;

Editor-in-Chief, Molecular Neurodegeneration

Guojun Bu, Ph.D., is a Professor of Neuroscience at Mayo Clinic Jacksonville. Prior to joining Mayo Clinic in 2010, he was a Professor in Cell Biology and Neuroscience in the Washington University School of Medicine in St. Louis. Dr. Bu received his B.S. degree in biology from Beijing Normal University and his Ph.D. degree in biochemistry from Virginia Tech. He is a leader in the field of apoE and apoE receptors, which play critical roles in the pathogenesis of Alzheimer’s disease (AD). His primary interest is to understand why APOE4 is a strong genetic risk factor for AD and how this pathway can be targeted for therapy. His laboratory is also exploring the potentials of human skin fibroblast-derived stem cells in the replacement of lost neurons and blood vessels in AD and vascular dementia. Dr. Bu has received several honors and awards including the Faculty Scholar Award and the Zenith Fellows Award from the Alzheimer’s Association and the Established Investigator Award from the American Heart Association. He is the Editor-in-Chief of Molecular Neurodegeneration and serves in review panels for the National Institutes of Health and the BrightFocus Foundation.

Funded Research

Project Description Researchers Funding
ABCA7 in Brain Homeostasis and Alzheimer's Disease

Genetic and environmental factors influence the risk of late-onset Alzheimer's disease; genetic studies have identified novel risk genes for the disease. ABCA7 is the gene encoding ATP-binding cassette sub-family A member 7; variants of ABCA7, which shares a homology with ABCA1, have shown a strong association with increased risk for late-onset Alzheimer’s disease. Importantly, loss-of-function variants in ABCA7 also have been demonstrated to significantly increase Alzheimer’s disease risk.

2015 to 2017

$400,000
Effects of Peripheral APOE on Central Nervous System Functions and AD Pathogenesis

Alzheimer’s disease, as the leading cause of dementia, has become a growing epidemic in our aging society. While aging is the greatest risk factor for AD development, a growing list of genetic and environmental factors also contributes to the risk. Among them, a gene called APOE is the strongest genetic risk factor for AD. The goal of the APOE consortium is to collectively address how a specific gene form called APOE4, which encodes the APOE4 protein, drives up the risk, and how we can target this protein for the development of new therapy.

2017
$250,000
Vascular Regenerative Therapy for Alzheimer’s Disease

Alzheimer’s disease (AD) is a major cause of dementia in elderly. The amyloid-β (Aβ) peptides deposit in the brain parenchyma as senile plaques and in the cerebrovasculature as cerebral amyloid angiopathy (CAA), both are hallmarks of AD pathology. Epidemiologically, cerebrovascular damages caused by diabetes mellitus or stroke increase the risk for AD. Cerebral hypoperfusion precedes cognitive decline and neurodegeneration in AD. Our recent work has also demonstrated that cerebrovasculature plays critical roles in Aβ clearance.

2013
$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu, APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14), 15 Jul 2017, 2690-2700
Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu, Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7), Jul 2017, 1267-1281
Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen, TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers In Aging Neuroscience, 9, 21 Jun 2017, 204
Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu, Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53, May 2017, 112-121
Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, and Takahisa Kanekiyo, ABCA7 Deficiency Accelerates Amyloid- Generation and Alzheimer’s Neuronal Pathology, Neurobiology of Disease, 36(13), 30 Mar 2016, 3848–3859
Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch-Daiello, Xianlin Han, John D. Fryer, Guojun Bu, APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations, Annals of Neurology, 79(5), 2 Mar 2016, 758-774
Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G, Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), The Journal of Biological Chemistry, 290(43), Oct 2015, 26043-50
, Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T, Journal of Biological Chemistry, 290(22), May 2015, 14208-14217
Chia-Chen Liu, Jin Hu, Chih-Wei Tsai, Mei Yue, Heather L. Melrose, Takahisa Kanekiyo, and Guojun Bu, Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, The Journal of Neuroscience, 35(14), April 2015, 5851-5859