Hansang Cho, Ph.D.

Assistant Professor, University of North Carolina at Charlotte

Dr. Hansang Cho is a member of the Center for Biomedical Engineering and Science and a professor in the Department of Mechanical Engineering and Engineering Science (Bioengineering Division) and the Department of Biological Sciences (graduate program) at the University of North Carolina at Charlotte, and a visiting scientist at Harvard Medical School/Massachusetts General Hospital (MGH).

Dr. Cho received his Ph.D. in the Department of Bioengineering at University of California, Berkeley. Then Dr. Cho worked at Harvard Medical School/MGH as a research fellow to implement his expertise on brain-on chips for the study of Alzheimer’s disease and neurovascular diseases. Since he joined UNCC in 2014, his research has focused on organ-on-chips for new discoveries in the areas of neurosciences and cancer biology, innovative mechanical components evolving multiple physics, and portable platforms for health care diagnostics and environmental sustainability.

His work in developing several brain-on-chips and nanobiosensors has significantly advanced our understanding of the mechanisms in cellular and molecular levels of Alzheimer’s disease and cancer, as well as therapeutic development. He received the MGH-Office for Research Career Development research fellows poster celebration award of “Poster of Distinction” in 2012; the Korean-American professional community in biotechnology and pharmaceuticals (KASBP)-Green Cross Fellowship in 2011; the first place in the Bears Breaking Boundaries competition under the category of neglected diseases at UC-Berkeley in 2008; the Lawrence scholar program fellowship from Lawrence Livermore National Laboratory in 2007; and a fellowship supported by Intel Inc. in 2005.

 

Funded Research

Project Description Researchers Funding
A 3-D Human Neural Cell Culture System for Studying Neuron-Microglia Interaction in Alzheimer’s Disease

In this proposal, we aim to dramatically improve the current microglial chemotactic model into a hybrid brain model that recapitulates pathological cascades of Alzheimer’s disease, including beta-amyloid deposits, microglial recruitment/clearance of beta-amyloid, neurofibrillary tangles and possibly neuronal death. To do this, we have been collaborating closely with Drs. Doo Yeon Kim and Rudolph E. Tanzi (Massachusetts General Hospital) to combine their novel “three-dimensional Alzheimer’s in a dish” model with our microglial chemotactic model. Drs.

2015 to 2016

$300,000