Cure Alzheimer's Fund Cure Alzheimer's Fund

John Chen, M.D. Ph.D.

Dr. Chen is an Associate Professor at Harvard Medical School and Attending Clinician (Neuroradiology) at MGH. Dr. Chen is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency at MGH in 2004 and neuroradiology fellowship also at MGH in 2005. He has won multiple awards including the MGH Wyman Award, RSNA and Dana Foundation Awards, as well as grants from the NIH and DoD. He is the director of the newly established Institute for Innovation in Imaging at MGH. Dr. Chen’s laboratory performs basic and translational studies to better understand neuroinflammation. In particular, the laboratory investigates the roles of molecular pathways and innate immune processes related to activated microglia in important neurological diseases such as Alzheimer’s disease and multiple sclerosis. A key aspect of the research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately Dr. Chen hopes to advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.

Related Research:

Myeloperoxidase, Imaging and Treatment Target for Alzheimer’s Disease John Chen 2014-08-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Myeloperoxidase, Imaging and Treatment Target for Alzheimer’s Disease 2014

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., Gatz, M., Chui, H. C., Shumaker, S. A., Resnick, S. M., Espeland, M. A., Finch, C. E., & Chen, J. C. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models, Translational Psychiatry, January 1, 2017, Read More

Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers in Aging Neuroscience, June 21, 2017, Read More

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