Oleg Butovsky, Ph.D.
The Role of APOE in Microglia Regulation in Neurodegeneration
Microglia, the primary immune cells and the sensors of the brain, play a pivotal role in the maintenance of brain homeostasis, but lose their functionality during the course of aging and neurodegenerative diseases. There is a gap in our knowledge about how microglial function is maintained in healthy brain and how and why it is prone to dysregulation in Alzheimer’s disease. There is also a lack of understanding of how the prominent genetic risk factor, APOE, is involved in microglia regulation and function.