Oleg Butovsky, Ph.D.

Assistant Scientist, Brigham and Women's Hospital
Assistant Professor of Neurology, Harvard Medical School

Funded Research

Project Description Researchers Funding
The Role of APOE in Microglia Regulation in Neurodegeneration

Microglia, the primary immune cells and the sensors of the brain, play a pivotal role in the maintenance of brain homeostasis, but lose their functionality during the course of aging and neurodegenerative diseases. There is a gap in our knowledge about how microglial function is maintained in healthy brain and how and why it is prone to dysregulation in Alzheimer’s disease. There is also a lack of understanding of how the prominent genetic risk factor, APOE, is involved in microglia regulation and function.