Sidney Strickland, Ph.D.

Professor and Head, Patricia and John Rosenwald Laboratory of Neurobiology and Genetics; Dean, The David Rockefeller Graduate Program; Vice-President for Educational Affairs; The Rockefeller University, New York City.

Dr. Strickland’s lab works on the relationships between cognitive dysfunction and the circulatory system.  Specifically, they have shown that the Aβ peptide can both promote the formation and also inhibit the dissolution of blood clots.  The increased and persistent clots that result could contribute to Alzheimer’s disease and other dementias by causing insufficient blood flow to critical cells and by inducing chronic inflammation.  Dr. Strickland received his B.S. from Rhodes College in Memphis, TN, and his PhD from the University of Michigan.  

Funded Research

Project Description Researchers Funding
FX11 System’s Effect on Alzheimer’s Disease
Alzheimer’s disease (AD) results in neuronal death in the brain leading to cognitive problems. The disease is complex and in most cases is thought to have multiple contributing factors. Two systems that have been implicated in AD are blood coagulation and inflammation, since many AD patients have increased blockage of small cerebral blood vessels and increased brain inflammation. In this regard, one arm of the blood coagulation system can promote both the formation of blood clots and the initiation of inflammatory processes.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Daria Zamolodchikov, Sidney Strickland, A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease, Thrombosis Research, 141(2), May 2016, S59-S61