Tal Nuriel, Ph.D.

Postdoctoral Research Fellow
Columbia University Medical Center

Dr. Nuriel is a postdoctoral research fellow at the Columbia University Medical Center in the department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s disease and the Aging Brain. Dr. Nuriel received his Ph.D. from the Weill Cornell Graduate School for Medical Sciences in 2013, where his thesis work involved the use of mass spectrometry to investigate the ability of nitrosative and oxidative stress to modify proteins during numerous disease states. After completing his thesis work, Dr. Nuriel joined the laboratory of Dr. Karen Duff, a recognized leader in the Alzheimer’s field. Dr. Nuriel’s primary focus in the laboratory is the use of multi-omics platforms (transcriptomics, lipidomics and metabolomics) to study the role of APOE4 in the development of Alzheimer’s disease. These studies have led to intriguing new areas of investigation on APOE4 and Alzheimer’s disease, including the current study funded by Cure Alzheimer’s Fund. 

Funded Research

Project Description Researchers Funding
Investigating the Mechanism of Entorhinal Cortex Hypermetabolism in APOE4 Targeted Replacement Mice

Carriers of the APOE4 gene are at significantly increased risk for developing Alzheimer’s disease. We have discovered that aging mice that express the APOE4 gene possess increased activity in a region of the brain that is implicated in the development of Alzheimer’s disease, and we think this increased activity may be an important link between APOE4 and Alzheimer’s disease pathology. In order to understand the cause of this increased brain activity, we will utilize sophisticated techniques to measure important genes and proteins known to increase brain activity.