Evaluating TMEM106B Accumulation in Alzheimer’s Disease

2022, 2023

Recent studies investigating a new type of filament found in patients with Alzheimer’s disease and related disorders identified TMEM106B, a protein normally localized to the lysosome, as the protein constituent. The current project is focused on developing new tools to label TMEM106B, and to understand the significance of TMEM106B filament accumulation and its relationship to the disease course.

Funding to Date



Studies of Alternative Neurodegenerative Pathways, Translational


Leonard Petrucelli, Ph.D.

Casey Cook, Ph.D.