2022
Recent studies investigating a new type of filament found in patients with Alzheimer’s disease and related disorders identified TMEM106B, a protein normally localized to the lysosome, as the protein constituent. The current project is focused on developing new tools to label TMEM106B, and to understand the significance of TMEM106B filament accumulation and its relationship to the disease course.
$201,250
Studies of Alternative Neurodegenerative Pathways, Translational
Leonard Petrucelli, Ph.D.
Casey Cook, Ph.D.
Saul Villeda, | 2022
Srdjan D. Antic, Riqiang Yan, | 2022
Sangram Sisodia, | 2022
Evandro F. Fang, | 2022
Andrew Yang, | 2022
Sangram Sisodia, | 2022
Leonard Petrucelli, Casey Cook, | 2022
Mathieu Bourdenx, Karen Duff, | 2022