2022, 2023
Recent studies investigating a new type of filament found in patients with Alzheimer’s disease and related disorders identified TMEM106B, a protein normally localized to the lysosome, as the protein constituent. The current project is focused on developing new tools to label TMEM106B, and to understand the significance of TMEM106B filament accumulation and its relationship to the disease course.
$402,500
Studies of Alternative Neurodegenerative Pathways, Translational
Leonard Petrucelli, Ph.D.
Casey Cook, Ph.D.
Robert Vassar, | 2023
Rudy Tanzi, Nanda Kumar Navalpur Shanmugam, | 2023
Sangram S. Sisodia, | 2023
David Holtzman, | 2023
Laura Cox, | 2023
Se Hoon Choi, Christiane Wrann, | 2023
Sam Gandy, Yanzhuang Wang, | 2023
Marc Weinberg, Steven Arnold,