Brain Entry and Exit Consortium: Does Subarachnoid Lymphatic-Like Membrane Failure Compromise Glymphatic Clearance in Alzheimer’s Disease?


This proposal will test whether age-dependent atrophy and loss of barrier function of the recently discovered meningeal membrane named subarachnoid lymphatic-like membrane (SLYM) contributes to recirculation of cerebrospinal fluid and amyloid beta accumulation. 

Funding to Date



Studies of Alternative Neurodegenerative Pathways, Translational


Maiken Nedergaard, M.D., D.M.Sc.