Understanding How Human Brain Vascular Cells Mediate Genetic Risk for Alzheimer’s Disease

2022, 2024

The risk for late-onset Alzheimer’s disease (AD) involves dozens of risk variants operating in diverse cell types. Elucidating the functions of these risk variants is critical to inform treatments but is challenging, in part because the vascular half of human brain cell types has eluded powerful single-cell assays. We will use our new vascular-capturing “VINE-seq” technique to comprehensively determine the cells and genes dysregulated by AD variants. We then will use chemical biology approaches to determine how identified AD variants dysregulate brain blood-brain barrier transport functions to compromise brain health and promote AD risk.

Funding to Date



Studies of Alternative Neurodegenerative Pathways, Translational


Andrew Yang, Ph.D.