We have coined the term CAPS to describe cross-linked-Beta-amyloid protein species. CAPS, particularly dimeric forms, are highly neurotoxic. CAPS are also abundant in vivo, with dimeric species alone comprising as much as 40 percent of the total Abeta pool in late state AD brain. In this study we plan to screen compound libraries for potential therapeutic agents that attenuate the levels and/or cytotoxic activity of CAPS.
Studies of APP and Abeta, Translational
Robert Moir, Ph.D.
Rudy Tanzi, Ph.D.
Meytal Landau, | 2022
Mehdi Jorfi, Joseph Park, Rudy Tanzi, | 2021
Caleb Finch, Michael A. Bonaguidi, | 2021
Raja Bhattacharyya, Rudy Tanzi, | 2021
Deepak Kumar Vijaya Kumar, Nanda Kumar Navalpur Shanmugam, Rudy Tanzi, William Eimer, | 2020
Gentry Patrick, | 2020
Nanda Kumar Navalpur Shanmugam, Deepak Kumar Vijaya Kumar, Rudy Tanzi, William Eimer, | 2020
William Eimer, Deepak Kumar Vijaya Kumar, Rudy Tanzi, | 2019