Cure Alzheimer's Fund Cure Alzheimer's Fund

Identification of Agents that Inhibit the Generation and Neurotoxicity of Cross-linked B-amyloid Protein Species

2006, 2007

We have coined the term CAPS to describe cross-linked-Beta-amyloid protein species. CAPS, particularly dimeric forms, are highly neurotoxic. CAPS are also abundant in vivo, with dimeric species alone comprising as much as 40 percent of the total Abeta pool in late state AD brain. In this study we plan to screen compound libraries for potential therapeutic agents that attenuate the levels and/or cytotoxic activity of CAPS.

Robert Moir Rudy Tanzi Studies of APP and Abeta Translational

Funding to Date

$200,000

Focus

Studies of APP and Abeta, Translational

Researchers

Rudy Tanzi, Ph.D.

Robert Moir, Ph.D.

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