Cure Alzheimer's Fund Cure Alzheimer's Fund

Andrew S. Yoo, Ph.D.

Professor, Developmental Biology, Washington University School of Medicine in St. Louis

 

Dr, Andrew Yoo is a Professor in the Department of Developmental Biology at Washington University School of Medicine. He did his Ph.D. work in the laboratory of Dr. Iva Greenwald at Columbia University, followed by postdoctoral work with Dr. Gerald Crabtree at Stanford University. He has a long standing interest in understanding genetic pathways that specify cell fates during development, and currently studies the role of microRNAs in regulating the activity of chromatin remodeling complexes during neural development and conversion of non-neuronal cells into neurons. Dr. Yoo’s work is supported by the awards from NIH Director’s New Innovator Award, the Presidential Early Career Award for Scientists and Engineers, the Ellison Medical Foundation and the Edward J. Mallinckrodt Jr. Foundation.

Web: http://yoolab.wustl.edu

Related Research:

Dissecting Alzheimer’s Disease Phenotypes in Directly Reprogrammed Patient-Derived Neurons Andrew S. Yoo 2023-10-25 Neuronal Subtype-Specific Modeling of Alzheimer’s Disease by Direct Neuronal Reprogramming of Patient Fibroblasts Andrew S. Yoo 2022-02-17 Modeling Alzheimer’s Disease in Specific Subtypes of Human Neurons Through Direct Neuronal Reprogramming of Patient Fibroblasts Andrew S. Yoo 2016-04-26

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Dissecting Alzheimer’s Disease Phenotypes in Directly Reprogrammed Patient-Derived Neurons 2023, 2024

$460,000
Neuronal Subtype-Specific Modeling of Alzheimer’s Disease by Direct Neuronal Reprogramming of Patient Fibroblasts 2021

$172,500
Modeling Alzheimer’s Disease in Specific Subtypes of Human Neurons Through Direct Neuronal Reprogramming of Patient Fibroblasts 2016-2019, 2022

$817,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Cates, K., Yuan, L., Yang, Y., & Yoo, A. S. Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs, Cell Reports, January 4, 2025, Read More

Burbach, K. F., Wu, S., & Yoo, A. S. Notch inhibition enhances morphological reprogramming of microRNA-induced human neurons, Stem Cells, November 22, 2024, Read More

Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science, August 8, 2024, Read More

Lee, S. W., Oh, Y. M., Victor, M. B., Yang, Y., Chen, S., Strunilin, I., Dahiya, S., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1–TFEB pathway to Huntington’s disease neurodegeneration, Nature Aging, December 8, 2023, Read More

Oh, Y. M., Lee, S. W., & Yoo, A. S. Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration, Autophagy, February 8, 2023, Read More

Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy, Nature Neuroscience, October 27, 2022, Read More

Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E., & Yoo, A. S. Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons, Cell Stem Cell, June 2, 2022, Read More

Cates, K., McCoy, M. J., Kwon, J. S., Liu, Y., Abernathy, D. G., Zhang, B., Liu, S., Gontarz, P., Kim, W. K., Chen, S., Kong, W., Ho, J. N., Burbach, K. F., Gabel, H. W., Morris, S. A., & Yoo, A. S. Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs, Cell Stem Cell, January 7, 2021, Read More

Yoo, A. S. Modeling Adult-Onset Neurodegenerative Disorders with Human Neurons through Direct Neuronal Reprogramming, The FASEB Journal, April 1, 2019, Read More

Shcheglovitov, A., Rao, M., & Yoo, A. Special Issue on Stem Cell and Tissue Engineering in Development, Disease, and Repair, Developmental Dynamics, January 1, 2019, Read More

Lu, Y. L., & Yoo, A. S. Mechanistic insights into MicroRNA-induced Neuronal Reprogramming of Human Adult Fibroblasts, Frontiers in Neuroscience, August 2, 2018, Read More

Lee, S. W., Oh, Y. M., Lu, Y. L., Kim, W. K., & Yoo, A. S. MicroRNAs Overcome cell fate barrier by reducing EH2-controlled REST stability during neuronal conversion of human adult fibroblastrs, Developmental Cell, July 2, 2018, Read More

McCoy, M. J., Paul, A. J., Victor, M. B., Richner, M., Gabel, H. W., Gong, H., Yoo, A. S., & Ahn, T. H. LONGO: an R package for interactive gene length dependent analysis for neuronal identity, Bioinformatics, June 27, 2018, Read More

Victor, M. B., Richner, M., Olsen, H. E., Lee, S. W., Monteys, A. M., Ma, C., Huh, C. J., Zhang, B., Davidson, B. L., Yang, X. W., & Yoo, A. S. Striatal Neurons directly converted from Huntington’s disease patient fibroblast recapitulate age-associated disease phenotypes, Nature Neuroscience, February 5, 2018, Read More

Abernathy, D. G., Kim, W. K., McCoy, M. J., Lake, A. M., Ouwenga, R., Lee, S. W., Xing, X., Li, D., Lee, H. J., Heuckeroth, R. O., Dougherty, J. D., Wang, T., & Yoo, A. S. MicroRNAs induce a permissive chromatin environment that enabels neuronal subtype-specific reprogramming of adult human fibroblasts, Cell Stem Cell, September 7, 2017, Read More

Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts, eLife, September 20, 2016, Read More

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