These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
The Role of PICALM Mutations in Alzheimer’s Disease |
2015, 2017, 2018 $645,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Zhao, Z., & Zlokovic, B. V. Therapeutic TVs for Crossing Barriers in the Brain, Cell, July 23, 2020, Read More
Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo, Frontiers in Aging Neuroscience, April 29, 2020, Read More
Zhao, Z., & Zlokovic, B. V. Endothelial Tip Cell Finds Its Way with Piezo1, Neuron, October 14, 2020, Read More
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews, January 1, 2019, Read More
Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. Prion Protein Antagonists Rescue Alzheimer’s Amyloid-Beta Related Cognitive Deficits, Trends in Molecular Medicine, February 1, 2019, Read More
Zhao, Z., & Zlokovic, B. V. Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma?, Cell Reports Medicine, December 21, 2021, Read More
Kisler, K., Sagare, A. P., Lazic, D., Bazzi, S., Lawson, E., Hsu, C. J., Wang, Y., Ramanathan, A., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier, Molecular Neurodegeneration, January 27, 2023, Read More
Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration, October 19, 2018, Read More
Zeng, J., Wang, Y., Luo, Z., Chang, L. C., Yoo, J. S., Yan, H., Choi, Y., Xie, X., Deverman, B. E., Gradinaru, V., Gupton, S. L., Zlokovic, B. V., Zhao, Z., & Jung, J. U. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice, Cell Reports , April 9, 2019, Read More
Montagne, A., Zhao, Z., & Zlokovic, B. V. Alzheimer’s disease: A matter of blood-brain barrier dysfunction?, Journal of Experimental Medicine, 10/23/2017, Read More
Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S. S., Lee, S. A., Ge, J., Wang, S., Goldman, S. A., Zlokovic, B. V., Zhao, Z., & Jung, J. U. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy, Cell Stem Cell, November 3, 2016, Read More
Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., Miller, C. A., Schneider, J. A., Maeda, M., Maed Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance, Nature Neuroscience, May 25, 2015, Read More