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Katherine Sadleir, Ph.D.

Research Associate Professor, Neurology; Northwestern University Feinberg School of Medicine

Dr. Katherine Sadleir completed her Ph.D. at the University of Chicago, then did post-doctoral work in the lab of Dr. Robert Vassar at Northwestern University.  Her work has focused on understanding the toxic nature of the immediate plaque environment, specifically the relationships between amyloid plaque deposition, dystrophic neurite development, and microglial and astrocyte activation. In addition, she is studying how dystrophic neurites may link amyloid deposition to tau spreading.

https://sites.northwestern.edu/vassarlab/

Related Research:

Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology Katherine Sadleir Robert Vassar 2024-12-23 Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology Katherine Sadleir Robert Vassar 2023-01-18

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology 2024

$286,558.79

Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology 2022, 2023

$572,804.65

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Sadleir, K. R., Gomez, K. P., Edwards, A. E., Patel, A. J., Ley, M. L., Khatri, A. W., Guo, J., Mahesh, S., Watkins, E. A., Popovic, J., Karunakaran, D. K. P., Prokopenko, D., Tanzi, R. E., Bustos, B., Lubbe, S. J., Demonbruen, A. R., McNally, E. M., & Vassar, R. Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer’s disease model mice, Acta Neuropathologica, May 24, 2025, Read More

Chandra, S., Popovic, J., Singhal, N. K., Watkins, E. A., Dodiya, H. B., Weigle, I. Q., Salvo, M. A., Ramakrishnan, A., Chen, Z., Watson, J. T., Shetti, A., Piehl, N., Zhang, X., Cuddy, L. K., Sadleir, K. R., Schwulst, S. J., Prakriya, M., Gate, D., Sisodia, S. S., & Vassar, R. The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17, The Journal of Clinical Investigation, May 13, 2025, Read More

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