These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Sex-Biased Toll-Like Receptor 7 (TLR7) Signaling in Demyelination and Its Inhibition by Small Molecules |
2024 $402,500 |
|
Development of Human cGAS Inhibitors to treat Alzheimer’s Disease |
2021-2023 $750,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Wang, S., Qi, C., Rajpurohit, C., Ghosh, B., Xiong, W., Wang, B., Qi, Y., Hwang, S. H., Hammock, B. D., Li, H., Gan, L., & Zheng, H. Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model, Molecular Neurodegeneration, April 23, 2025, Read More
Alarcón-Espósito, J., Nagiri, R. K., Gan, L., & Sinha, S. C. Identification and development of cGAS inhibitors and their uses to treat Alzheimer’s disease, NeuroTherapeutics, January 31, 2025, Read More
Lopez-Lee, C., Kodama, L., Fan, L., Zhu, D., Zhu, J., Wong, M. Y., Ye, P., Norman, K., Foxe, N. R., Ijaz, L., Yu, F., Chen, H., Carling, G. K., Torres, E. R., Kim, R. D., Dubal, D. B., Liddelow, S. A., Sinha, S. C., Luo, W., & Gan, L. Tlr7 drives sex differences in age- and Alzheimer’s disease-related demyelination, Science, November 29, 2024, Read More
Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J., Cheng, F., … Gan, L. Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model, Neuron, September 24, 2024, Read More
Huang, Y., Liu, B., Sinha, S. C., Amin, S., & Gan, L. Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders, Molecular Neurodegeneration, November 8, 2023, Read More
Udeochu, J. C., Amin, S., … Tsai, L. H., Subhash, S. C., & Gan, L. Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience, Nature Neuroscience, April 24, 2023, Read More