June 2024



Cure Alzheimer’s Fund Presents the Jeffrey L. Morby Prize for Exceptional Research

Cure Alzheimer’s Fund announced the recipients of the inaugural Jeffrey L. Morby Prize. Senior author David M. Holtzman, M.D., and first author Xiaoying Chen, Ph.D., both of Washington University School of Medicine in St. Louis, were selected by their peers for their paper Microglia-Mediated T Cell Infiltration Drives Neurodegeneration in Tauopathy, published in Nature in March 2023. The Morby Prize is named in honor of our late Co-Founder, Jeffrey L. Morby, who inspired our mission 20 years ago to fund research as a path to ending Alzheimer’s disease.

 

Dr. David Holtzman and Jacqueline C. Morby

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Cure Alzheimer’s Fund Reaches $200 Million in Research Grants

Cure Alzheimer’s Fund has reached an important milestone—awarding more than $200 million in research grants to leading scientists throughout the world investigating Alzheimer’s disease, with support to more than 840 innovative grants led by more than 300 scientists resulting in 1,182 published peer-reviewed papers in prominent scientific journals. Many of these projects have yielded significant breakthroughs, resulting in findings contributing to new and critical avenues for the development of novel treatments.

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Webinar: The Puzzle of Sex, Gender, and Alzheimer’s Disease

 

Murali Doraiswamy, MBBS, FRCP

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The First Biomarker for Tau Tangles

Cure Alzheimer’s Fund researchers have identified a promising biomarker that could transform the early detection of Alzheimer’s disease (AD). This biomarker, measured in the cerebrospinal fluid, detects the type of tau found in tangles that accumulate in the brain.

 

David M. Holtzman, M.D., Washington University School of Medicine in St. Louis
John C. Morris, M.D., Washington University School of Medicine in St. Louis
Randall J. Bateman, M.D., Washington University School of Medicine in St. Louis
Rik Ossenkoppele, Ph.D., Lund University, Sweden
Oskar Hansson, M.D., Ph.D., Lund University, Sweden

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The Brain’s Blood Vessels Change in Alzheimer’s Disease

Changes in the blood vessels of the brain have been linked to Alzheimer’s disease (AD), and deterioration of the blood-brain barrier may be an early sign of the disease. But how the brain’s vasculature changes on the molecular level has remained largely unknown, hindering the development of therapies. A study profiling gene expression of the brain’s blood vessels revealed AD changes in unprecedented detail. The results provide a map to guide potential future therapies targeting blood-brain barrier dysfunction in Alzheimer’s.

Li-Huei Tsai, Ph.D. and Manolis Kellis, Ph.D.,
Massachusetts Institute of Technology; Broad Institute

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Thank You for Your Generosity

Thank you for your generosity as we continue to fund research into Alzheimer’s disease.

Giving takes many forms and we want to share a powerful way to contribute: Qualified Charitable Distributions (QCDs), also known as IRA Charitable Rollover Gifts. This opportunity allows those aged 70½ or older to direct up to $105,000 each year from their traditional IRA to a qualified charity like Cure Alzheimer’s Fund, with potential tax benefits.

To learn more, visit https://www.freewill.com/qcd/curealz. You may also contact Mahua Heath at [email protected]. To learn about all of the ways to donate to Cure Alzheimer’s Fund, please visit CureAlz.org/donate.

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—The Cure Alzheimer’s Fund Team