Cure Alzheimer's Fund Cure Alzheimer's Fund

Paula Grammas, Ph.D.

Chief Research Officer, Tribute Senior Living

Dr. Grammas is best known for her pioneering research into the role that blood vessels and inflammation play in the development of Alzheimer’s disease. She has been the principal investigator or co-investigator on more than $24 million in research grants from the National Institutes of Health and other agencies and foundations and has published 150 peer-reviewed research papers. A former professor of neurology and holder of the Mildred and Shirley Garrison Chair in Aging at the Texas Tech School of Medicine, she has received numerous awards for her Alzheimer’s research. Dr. Grammas received the Zenith Award from the Alzheimer’s Association in recognition of her accomplishments as one of the nation’s leading researchers on Alzheimer’s disease and was elected to the American Association for the Advancement of Science Circle of Fellows in recognition of her contributions to Alzheimer’s disease research. Dr. Grammas has served as Director of the Oklahoma Center for Neuroscience at the University of Oklahoma Health Science Center, Executive Director of the Garrison Institute on Aging at the Texas Tech University Health Sciences Center, and Inaugural Executive Director of the Ryan Institute for Neuroscience at the University of Rhode Island.

 

Related Research:

Cerebrovascular Dysfunction in AD: Targeting the Mechanisms of Vascular Activation Paula Grammas 2018-08-09

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Cerebrovascular Dysfunction in AD: Targeting the Mechanisms of Vascular Activation 2017 and 2019

$206,404

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Iannucci, J., Johnson, S. L., Majchrzak, M., Barlock, B. J., Akhlaghi, F., Seeram, N. P., Sen, A., & Grammas, P. Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer’s disease mouse model, Biochemistry and Biophysics Reports, November 19, 2020, Read More

Iannucci, J., Rao, H. V., & Grammas, P. High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro, Cellular and Molecular Neurobiology, November 2, 2020, Read More

Bihaqi, S. W., Rao, H. V., Sen, A., & Grammas, P. Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer’s disease, Cerebral Circulation - Cognition and Behavior, May 6, 2021, Read More

Iannucci, J., Sen, A., & Grammas, P. Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro, Current Issues in Molecular Biology, May 27, 2021, Read More

Iannucci, J., Renehan, W., & Grammas, P. Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease, Frontiers in Neuroscience, July 24, 2020, Read More

Mattar, J. M., Majchrzak, M., Iannucci, J., Bartman, S., Robinson, J. K., & Grammas, P. Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice, International Journal of Molecular Sciences, April 1, 2022, Read More

Vittal Rao, H., Bihaqi, S. W., Iannucci, J., Sen, A., & Grammas, P. Thrombin Signaling Contributes to High Glucose-Induced Injury of Human Brain Microvascular Endothelial Cells., Journal of Alzheimer's disease, January 5, 2021, Read More

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