Paul Greengard, Ph.D.

The Rockefeller University, Nobel Laureate

Dr. Paul Greengard was a pioneer in understanding how brain cells communicate, and his work was rewarded with the Nobel Prize in Physiology or Medicine.

Cure Alzheimer’s Fund was privileged to begin working with Dr. Greengard in 2006. So many of the researchers funded by CureAlz looked to Dr. Greengard for his expertise, but also for his willingness to be a mentor, as he truly was committed to the success of others. “Paul was clearly one of the greatest neuroscientists that ever lived; he was a true giant among all scientists,” said Dr. Rudy Tanzi. “His legacy of brilliance, originality and unwavering curiosity about the brain, together with his incomparable degree of kindness, generosity and respect for everyone he knew, will be fondly remembered for a long time. While we have lost one of the greatest scientists who ever lived, there is no doubt that his lifelong body of work will inspire innumerable new discoveries for many decades to come.”

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6), 7 Feb 2017, 1389–1394, Read More

Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer’s Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP, The Journal of Neuroscience, 30(17), Apr 28 2010, 5948-5957, Read More

Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation, Neuron, 64(3), Nov 12, 2009, 328-40, Read More

Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A Cdk5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Science, Vol. 105 No. 47, October 9, 2008, 18567-18571, Read More