Paul Greengard, Ph.D.

The Rockefeller University, Nobel Laureate

Dr. Paul Greengard was a pioneer in understanding how brain cells communicate, and his work was rewarded with the Nobel Prize in Physiology or Medicine.

Cure Alzheimer’s Fund was privileged to begin working with Dr. Greengard in 2006. So many of the researchers funded by CureAlz looked to Dr. Greengard for his expertise, but also for his willingness to be a mentor, as he truly was committed to the success of others. “Paul was clearly one of the greatest neuroscientists that ever lived; he was a true giant among all scientists,” said Dr. Rudy Tanzi. “His legacy of brilliance, originality and unwavering curiosity about the brain, together with his incomparable degree of kindness, generosity and respect for everyone he knew, will be fondly remembered for a long time. While we have lost one of the greatest scientists who ever lived, there is no doubt that his lifelong body of work will inspire innumerable new discoveries for many decades to come.”

Related Research:

Impact of APOE and Sex on Vulnerable Neuron-Specific Functional Network Paul Greengard 2017-07-25 Uncovering Determinants of Neuronal Vulnerability in Alzheimer’s Disease Paul Greengard 2015-09-24 Selective Cell Vulnerability in Alzheimer’s Disease Paul Greengard 2011-11-11 Oligomer Collaborative Projects Charles Glabe David Holtzman Paul Greengard Rudy Tanzi Sam Gandy Sangram S. Sisodia Stephen Strittmatter Tae-Wan Kim Virginia Lee 2011-03-01

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry, August 13, 2020, Read More

Bettayeb, K., Hooli, B. V., Parrado, A. R., Randolph, L., Varotsis, D., Aryal, S., Gresack, J., Tanzi, R. E., Greengard, P., & Flajolet, M. Relevance of the COPI complex for Alzheimer’s disease progression in vivo, Proceedings of the National Academy of Sciences of the United States of America, April 25, 2016, Read More

Hur, J. Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Vassar, R., … Greengard, P., ... Li, Y. M. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease, Nature, September 2, 2020, Read More

Zhang, Y., Kurup, P., Xu, J., Anderson, G. M., Greengard, P., Nairn, A. C., & Lombroso, P. J. Reduced levels of the tyrosine phosphatase STEP block beta-amyloid-mediated GluA1/GluA2 receptor internalization, Journal of Neurochemistry, September 21, 2011, Read More

Kurup, P., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V., Greengard, P., Nairn, A. C., & Lombroso, P. J. A beta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61, Journal of Neuroscience, April 28, 2010, Read More

Zhang, Y. W., Liu, S., Zhang, X., Li, W. B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W. J., Threadgill, R., Wiegand, G., Wang, R., Cohen, S. N., Greengard, P., Liao, F. F., Li, L., & Xu, H. A functional mouse retroposed gene Rps23r1 reduces Alzhiemer’s beta amyloid levels and tau phosphorylation, Neuron, November 12, 2009, Read More

Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A., & Eisch, A. J. CDK5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Sciences of the United States of America, November 18, 2008, Read More

Netzer, W. J., Bettayeb, K., Sinha, S. C., Flajolet, M., Greengard, P., & Bustos, V. Gleevec shifts APP processing from a beta-cleavage to a nonamyloidogenic cleavage, Proceedings of the National Academy of Sciences of the United States of America, January 23, 2017, Read More

Bettayeb, K., Chang, J. C., Luo, W., Aryal, S., Varotsis, D., Randolph, L., Netzer, W. J., Greengard, P., & Flajolet, M. δ-COP modulates Aβ peptide formation via retrograde trafficking of APP, Proceedings of the National Academy of Sciences of the United States of America, April 25, 2016, Read More

Liebmann, T., Renier, N., Bettayeb, K., Greengard, P., Tessier-Lavigne, M., & Flajolet, M. Three-dimensional study of Alzheimer’s disease hallmarks using iDISCO clearing method, Cell Reports, July 14, 2016, Read More

Ledo, J. H., Zhang, R., Mesin, L., Mourão-Sá, D., Azevedo, E. P., Troyanskaya, O. G., Bustos, V., & Greengard, P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development, PLoS One, August 21, 2020, Read More

Pulina, M. V., Hopkins, M., Haroutunian, V., Greengard, P., & Bustos, V. C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease, Alzheimer's & Dementia, January 6, 2020, Read More

Roussarie, J. P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P. R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O. G., … Greengard, P. Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis, Neuron, June 29, 2020, Read More