These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Impact of APOE and Sex on Vulnerable Neuron-Specific Functional Network |
2017, 2018 $500,000 |
|
Uncovering Determinants of Neuronal Vulnerability in Alzheimer’s Disease |
2015, 2016 $500,000 |
|
Selective Cell Vulnerability in Alzheimer’s Disease |
2011 $100,000 |
|
Oligomer Collaborative Projects |
2006 $1,550,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry, August 13, 2020, Read More
Hur, J. Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Vassar, R., … Greengard, P., ... Li, Y. M. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease, Nature, September 2, 2020, Read More
Zhang, Y., Kurup, P., Xu, J., Anderson, G. M., Greengard, P., Nairn, A. C., & Lombroso, P. J. Reduced levels of the tyrosine phosphatase STEP block beta-amyloid-mediated GluA1/GluA2 receptor internalization, Journal of Neurochemistry, September 21, 2011, Read More
Kurup, P., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V., Greengard, P., Nairn, A. C., & Lombroso, P. J. A beta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61, Journal of Neuroscience, April 28, 2010, Read More
Zhang, Y. W., Liu, S., Zhang, X., Li, W. B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W. J., Threadgill, R., Wiegand, G., Wang, R., Cohen, S. N., Greengard, P., Liao, F. F., Li, L., & Xu, H. A functional mouse retroposed gene Rps23r1 reduces Alzhiemer’s beta amyloid levels and tau phosphorylation, Neuron, November 12, 2009, Read More
Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A., & Eisch, A. J. CDK5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Sciences of the United States of America, November 18, 2008, Read More
Netzer, W. J., Bettayeb, K., Sinha, S. C., Flajolet, M., Greengard, P., & Bustos, V. Gleevec shifts APP processing from a beta-cleavage to a nonamyloidogenic cleavage, Proceedings of the National Academy of Sciences of the United States of America, January 23, 2017, Read More
Bettayeb, K., Chang, J. C., Luo, W., Aryal, S., Varotsis, D., Randolph, L., Netzer, W. J., Greengard, P., & Flajolet, M. δ-COP modulates Aβ peptide formation via retrograde trafficking of APP, Proceedings of the National Academy of Sciences of the United States of America, April 25, 2016, Read More
Liebmann, T., Renier, N., Bettayeb, K., Greengard, P., Tessier-Lavigne, M., & Flajolet, M. Three-dimensional study of Alzheimer’s disease hallmarks using iDISCO clearing method, Cell Reports, July 14, 2016, Read More
Ledo, J. H., Zhang, R., Mesin, L., Mourão-Sá, D., Azevedo, E. P., Troyanskaya, O. G., Bustos, V., & Greengard, P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development, PLoS One, August 21, 2020, Read More
Pulina, M. V., Hopkins, M., Haroutunian, V., Greengard, P., & Bustos, V. C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease, Alzheimer's & Dementia, January 6, 2020, Read More
Roussarie, J. P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P. R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O. G., … Greengard, P. Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis, Neuron, June 29, 2020, Read More
Bettayeb, K., Hooli, B. V., Parrado, A. R., Randolph, L., Varotsis, D., Aryal, S., Gresack, J., Tanzi, R. E., Greengard, P., & Flajolet, M. Relevance of the COPI complex for Alzheimer’s disease progression in vivo, Proceedings of the National Academy of Sciences of the United States of America, April 25, 2016, Read More