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Sandro Da Mesquita, Ph.D.

Assistant Professor of Neuroscience, Mayo Clinic College of Medicine and Science, Jacksonville.

Sandro Da Mesquita, Ph.D., is an assistant professor of neuroscience in the Mayo Clinic College of Medicine and Science in Jacksonville, Florida. Dr. Da Mesquita’s research focuses on the pathophysiology of brain aging and neurological disorders, with special interest in the role of the recently characterized meningeal lymphatic system. His main goals are to advance the basic knowledge of disease mechanisms involving meningeal lymphatics and to develop novel bench-to-bedside therapeutic strategies to prevent age-associated neurodegeneration and cognitive decline, particularly in the context of Alzheimer’s disease.

Links:

Da Mesquita Lab – Meningeal Lymphatics and Neurological Disorders

Da Mesquita profile page – Mayo Clinic

Follow on Twitter – @Da_Mesquita_S

 

 

Related Research:

Restore Meningeal Lymphatic Drainage to Alleviate White Matter Damage and Cerebral Amyloid Angiopathy in a Model of Alzheimer’s Disease Sandro Da Mesquita 2023-12-09 Harnessing Meningeal Lymphatics and Immunity to Alleviate APOE4-Induced Brain Dysfunction Sandro Da Mesquita 2022-02-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Restore Meningeal Lymphatic Drainage to Alleviate White Matter Damage and Cerebral Amyloid Angiopathy in a Model of Alzheimer’s Disease 2023, 2024

$402,500
Harnessing Meningeal Lymphatics and Immunity to Alleviate APOE4-Induced Brain Dysfunction 2021, 2022

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kloske, C. M., Mahinrad, S., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Butts, B., Carrillo, M. C., Chakrabarty, P., Chen, X., Craft, S., Da Mesquita, S., ... Lemere, C. A., Liddelow, S. A., Quintana, F. J., … Wilcock, D. M. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference, Alzheimer's & Dementia, December 18, 2024, Read More

Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain, October 21, 2024, Read More

das Neves, S. P., Delivanoglou, N., Ren, Y., Cucuzza, C. S., Makuch, M., Almeida, F., Sanchez, G., Barber, M. J., Rego, S., Schrader, R., Faroqi, A. H., Thomas, J. L., McLean, P. J., Oliveira, T. G., Irani, S. R., Piehl, F., & Da Mesquita, S. Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination, Immunity, August 31, 2024, Read More

Funk, K. E., Montagne, A., Falcao, A. M., & Da Mesquita, S. Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain, Frontiers in Cellular Neuroscience, June 8, 2022, Read More

Da Mesquita S. Charting the meningeal lymphatic network, Journal of Experimental Medicine, July 5, 2022, Read More

Rego, S., Sanchez, G., & Da Mesquita, S. Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease, Molecular Neurodegeneration, August 14, 2023, Read More

Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., Rich, S. S., Dominantly Inherited Alzheimer Network, Benitez, B. A., Karch, C. M., Perrin, R. J., Farlow, M., Chhatwal, J. P., Holtzman, D. M., Cruchaga, C., Harari, O., & Kipnis, J. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy, Nature, April 28, 2021, Read More

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