These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Elucidating the Role of CLEC7A in Tau-Mediated Neurodegenerative Disease |
2023, 2024 $402,500 |
|
Targeting a Master Innate Immune Adaptor Molecule in Alzheimer’s Disease |
2021, 2022 $345,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Samuels, J. D., & Lukens, J. R. Myelin debris as an initiator of microglial dysfunction and neuropathology in Alzheimer’s disease, Cellular & Molecular Immunology, January 14, 2025, Read More
Hollis, A., & Lukens, J. R. Role of inflammasomes and neuroinflammation in epilepsy, Immunological Reviews, November 10, 2024, Read More
Samuels, J. D., Moore, K. A., Ennerfelt, H. E., Johnson, A. M., Walsh, A. E., Price, R. J., & Lukens, J. R. The Alzheimer’s disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology, Alzheimer's & Dementia, April 15, 2023, Read More
Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., & Lukens, J. R. SYK coordinates neuroprotective microglial responses in neurodegenerative disease, Cell, October 17, 2022, Read More
Ennerfelt, H., & Lukens, J. R. Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer’s disease and multiple sclerosis, Clinical and Translational Medicine, January 11, 2023, Read More
Mangalmurti A, Lukens JR. How neurons die in Alzheimer’s disease: Implications for neuroinflammation, Current Opinion in Neurobiology, June 10, 2022, Read More
Johnson, A. M., & Lukens, J. R. The innate immune response in tauopathies, European Journal of Immunoogy, March 18, 2023, Read More
Lukens, J. R., & Williams, J. L. An introduction to neuroimmunology, Immunological Reviews, August 30, 2022, Read More
Samuels, J. D., Lukens, J. R., & Price, R. J. Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer’s disease-related amyloidosis, Journal of Neurochemistry, October 11, 2023, Read More
Ennerfelt, H., Holliday, C., Shapiro, D. A., Zengeler, K. E., Bolte, A. C., Ull|, T. K., & Lukens, J. R. CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model, Proceedings of the National Academy of Sciences of the United States of America, June 5, 2023, Read More