These projects were made possible from Cure Alzheimer's Fund support.
| Project Description | Researchers | Funding |
|---|---|---|
| Role of Checkpoint Molecules TIM-3 and LAG-3 in Microglial Regulation and Alzheimer’s Disease Pathology |
2026 $201,250 |
|
| Fleming APOE Consortium: APOE4 Accelerates CD8 Exhaustion via Glucocorticoid Signaling in Alzheimer’s Female Carriers |
2024, 2025 $1,150,000 |
|
| A New Model of Microglia Genetic Perturbation in Vivo to Screen All Risk Factors Associated with Alzheimer’s Disease |
2023, 2025 $862,500 |
|
| Role of Checkpoint Molecules TIM-3 and LAG-3 in Microglial Function in Alzheimer’s Disease |
2023, 2024 $402,500 |
|
| Role of Checkpoint Molecule TIM-3 in Regulating Microglia in Alzheimer’s Disease |
2021, 2022 $345,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Butovsky, O., Rosenzweig, N., Kleemann, K. L., Jorfi, M., Kuchroo, V. K., Tanzi, R. E., & Weiner, H. L. Immune dysfunction in Alzheimer disease, Nature reviews. Neuroscience, November 28, 2025, Read More
Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., Guzchenko, I., Zhang, X., ... Selkoe, D., Weiner, H. L., Blurton-Jones, M., Cruchaga, C., … Butovsky, O., Kuchroo, V. K. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease, Nature, April 9, 2025, Read More