Cure Alzheimer's Fund Cure Alzheimer's Fund

Weiming Xia, Ph.D.

Professor, Pharmacology and Experimental Therapeutics, Boston University School of Medicine

Dr. Weiming Xia received his bachelor of science degree from Fudan University, China and Ph.D. degree from the University of Texas Medical School at Houston, Texas, USA. He pursued postdoctoral training in Dr. Dennis Selkoe’s laboratory in 1995 and joined the faculty at the Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School in 1999. During 2009-2012, Dr. Xia devoted his effort to developing Alzheimer therapeutics in a start-up company before he returned to academia at Veteran Affairs Hospital and Boston University School of Medicine. Currently he is the acting Associate Director of Research at the Geriatric Research Education and Clinical Center at the Bedford VA Hospital. Dr. Xia has over 20 years of experience in target identification, characterization, validation and early stage drug development, with exploration of clinical biomarkers for Alzheimer’s disease. His lab has established a number of in vitro, cellular, and zebrafish-based high-content, whole-animal assays to characterize drug targets. Dr. Xia has published over 100 original research articles, reviews/book chapters and edited a book. His research, currently supported by NIH, the Department of Veteran Affairs, and Cure Alzheimer’s Fund, focuses on the molecular mechanisms responsible for pathological changes in AD, on biomarkers reflecting disease progression, and on exploration and discovery of therapeutic interventions.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Alzheimer’s Disease Drug Discovery and Development Consortium: Blocking Synaptotoxicity in Alzheimer’s Three-Dimensional Models 2021, 2022

$370,000
Proteomics of Alzheimer’s Disease Three-Dimensional Cultures 2020

$172,500
Alzheimer’s Disease Pharmacomics in 3-D 2018 to 2019

$345,000
Alzheimer’s Disease Stem Cell Drug Screening in 3-D 2017

$100,000
3DDS: Alzheimer’s Disease Drug Discovery in 3-D 2015 to 2016

$300,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1), Jul 2017, 31-44, Read More

Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J. Morin, John M. Wells, Eugene B. Hanlon, Weiming Xia Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells, PLOS ONE, 11(9), 29 September 2016, Read More

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