Zhongcong Xie, M.D., Ph.D.

Funded in 2011 for work on “Surgery-induced Brain Inflammation Interacting With Genetic Mutation-Induced Elevated A-beta, Leading to Memory Impairment”

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
General Anesthetics and Alzheimer’s Disease 2012

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Quan Ren, Mian Peng, Yuanlin Dong, Yiying Zhang, Ming Chen, Ning Yin, Edward R. Marcantonio, and Zhongcong Xie Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience, 9, September 2015, 346, Read More

H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang and Z. Xie Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors, Br. J. Anaesth., Read More

Zhongcong Xie, Celeste A. Swain, Sarah A. P. Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W. Burke, Diana Escobar, Yiying Zhang and Edward R. Marcantonio Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium, Annals of Clinical and Translational Neurology, 9 April 2014, Read More

Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4, January 20, 2014, 3766, Read More

Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice, J Neurosci, 33(45), November 6, 2013, 17737-17748, Read More

Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00, 5/10/2013, 1-6, Read More, Download Paper

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, Br. J. Anaesth., 111(2), May 30, 2013, 143-151, Read More

Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia, April 19, 2013, Read More

Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment, Anesthesiology, Jan 9, 2013, Read More

Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Curr Mol Med., Sep 3, 2012, Read More

Xie Z, Xu Z General anesthetics and β-amyloid protein, Prog Neuropsychopharmacol Biol Psychiatry, Aug 14, 2012, 140-146, Read More

Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β, Neurobiology of Aging, 33(7), July 2012, 1364-78, Read More

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing, Transl Neurodegener., 1:8, Mar 22, 2012, Read More

Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,* Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory, Annals of Neurology, Volume 71, Issue 5, February 24, 2012, 687–698, Read More

Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation, PLoS One, 7(6), 2012, Read More

Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE.  The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64, Dec 2008, Read More

Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18), May 2, 2008, 11866-75, Read More

Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine., J Neurosci, 28, April 23, 2008, 4551-60, Read More

Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE. The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation., J. Neurosci., 27, 2007, 1247-1254, Read More