Zhongcong Xie, M.D., Ph.D.

Funded in 2011 for work on “Surgery-induced Brain Inflammation Interacting With Genetic Mutation-Induced Elevated A-beta, Leading to Memory Impairment”

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
General Anesthetics and Alzheimer’s Disease 2012

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Zhang, L., Zhang, J., Yang, L., Dong, Y., Zhang, Y., & Xie, Z. Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia, April 19, 2013, Read More

Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology, November 11, 2008, Read More

Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging, December 28, 2010, Read More

Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease, October 1, 2010, Read More

Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery, August 1, 2013, Read More

Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology, January 19, 2023, Read More

Xie, Z., & Xu, Z. General anesthetics and beta-amyloid protein, Progress in Neuro-Psychopharmacology & Biological Psychiatry, August 13, 2012, Read More

Dong, Y., Wu, X., Xu, Z., Zhang, Y., & Xie, Z. Anesthetic isoflurante increases phosphorylated tau levels mediated by caspase activation and A beta generation, PLoS One, June 20, 2012, Read More

Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A., Xue, Z., Miao, C., Zhang, Y., Chamberlin, N. L., & Xie, Z. Sleep disturbance induces neuroinflammation and impariment of learning and memory, Neurobiology of Disease, December 1, 2012, Read More

Cheng, B., Zhang, Y., Wang, A., Dong, Y., & Xie, Z. Vitamin C attenuates isoflurane-induced caspase-3 activation and cognitive impairment, Molecular Neurobiology, November 4, 2014, Read More

Zhang, J., Dong, Y., Zhou, C., Zhang, Y., & Xie, Z. Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95, Molecular Neurobiology, May 29, 2014, Read More

Terrando, N., Brzezinski, M., Degos, V., Eriksson, L. I., Kramer, J. H., Leung, J. M., Miller, B. L., Seeley, W. W., Vacas, S., Weiner, M. W., Yaffe, K., Young, W. L., Xie, Z., & Maze, M. Perioperative cognitive decline in aging population, MAYO Clinic Proceedings, September 1, 2011, Read More

Zhang, X., Xin, X., Dong, Y., Zhang, Y., Yu, B., Mao, J., & Xie, Z. Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA recptor 2B in mice, Journal of Neuroscience, November 6, 2013, Read More

Ren, Q., Peng, M., Dong, Y., Zhang, Y., Chen, M., Yin, N., Marcantonio, E. R., & Xie, Z. Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience, September 8, 2015, Read More

Zhang, Y., Pan, C., Wu, X., Dong, Y., Culley, D. J., Crosby, G., Li, T., & Xie, Z. Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochorne mice levels between m neural progenitor cells and neurons, Frontiers in Cellular Neuroscience, January 30, 2014, Read More

Vlisides, P., & Xie, Z. Neurotoxicity of General Anesthetics: an update, Current Pharmaceutical Design, December 1, 2012, Read More

Wang, H., Dong, Y., Zhang, J., Xu, Z., Wang, G., Swain, C. A., Zhang, Y., & Xie, Z. Isoflurane induces endoplasmic reticulum stress and caspase actication through ryanodine receptors, British Journal of Anaesthesia, April 3, 2014, Read More

Jevtovic-Todorovic, V., Absalom, A. R., Blomgren, K., Brambrink, A., Crosby, G., Culley, D. J., Fiskum, G., Giffard, R. G., Herold, K. F., Loepke, A. W., Ma, D., Orser, B. A., Planel, E., Slikker, W., Jr, Soriano, S. G., Stratmann, G., Vutskits, L., Xie, Z., & Hemmings, H. C., Jr. Anaesthetic Neurotoxicity and Neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, British Journal of Anaesthesia, August 1, 2013, Read More

Tao, G., Zhang, J., Zhang, L., Dong, Y., Yu, B., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3 beta activation in young mice, Anesthesiology, September 1, 2014, Read More

Li, X. M., Su, F., Ji, M. H., Zhang, G. F., Qiu, L. L., Jia, M., Gao, J., Xie, Z., & Yang, J. J. Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitvie impariment induced by isoflurane in aged mice, Anesthesiology, July 1, 2014, Read More

Xie Z. Cancer prognosis: can anesthesia play a role?, Anesthesiology, September 1, 2013, Read More

Zhang, B., Tian, M., Zheng, H., Zhen, Y., Yue, Y., Li, T., Li, S., Marcantonio, E. R., & Xie, Z. Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and τ Level, Anesthesiology, July 1, 2013, Read More

Zheng, H., Dong, Y., Xu, Z., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice, Anesthesiology, March 1, 2013, Read More

Shen, X., Dong, Y., Xu, Z., Wang, H., Miao, C., Soriano, S. G., Sun, D., Baxter, M. G., Zhang, Y., & Xie, Z. Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment, Anesthesiology, March 1, 2013, Read More

Sun, Y., Zhang, Y., Cheng, B., Dong, Y., Pan, C., Li, T., & Xie, Z. Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells, ​​Anesthesia & Analgesia, July 26, 2014, Read More

Yuan, J., Cui, G., Li, W., Zhang, X., Wang, X., Zheng, H., Zhang, J., Xiang, S., & Xie, Z. Propofol Enhances Hemoglobin-induced cytotoxicity in Neurons, ​​Anesthesia & Analgesia, January 14, 2016, Read More

Wang, H., Xu, Z., Wu, A., Dong, Y., Zhang, Y., Yue, Y., & Xie, Z. 2-Deoxy-D-Glucose Enhances Anesthetic Effects in Mice, ​​Anesthesia & Analgesia, February 1, 2015, Read More

Yang, L., Xin, X., Zhang, J., Zhang, L., Dong, Y., Zhang, Y., Mao, J., & Xie, Z. Inflammatory pain may induce cognitive impairment through an interlukin-6 dependent and postsynaptic density-95 associated mechanism, ​​Anesthesia & Analgesia, May 30, 2014, Read More

Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Scientific Reports, January 20, 2014, Read More

Lee, I. H., Culley, D. J., Baxter, M. G., Xie, Z., Tanzi, R. E., & Crosby, G. Spatial memory is intact in aged rats after propofol anesthesia, ​​Anesthesia & Analgesia, October 1, 2008, Read More

Dong, Y., Wu, X., Zhang, G., Xu, Z., Zhang, Y., Gautam, V., Kovacs, D. M., Wu, A., Yue, Y., & Xie, Z. Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Current Molecular Medicine, May 1, 2013, Read More