Cure Alzheimer's Fund Cure Alzheimer's Fund

Scott Noggle, Ph.D.

Scott A. Noggle, Ph.D., Principal Investigator of NYSCF’s scientific team, is conducting research at NYSCF’s state-of-the-art laboratory and also serves as a technical and scientific resource to other researchers working in the laboratory. Scott previously managed the Tri-Institutional Stem Cell Initiative’s Derivation Core facility at The Rockefeller University for two years. He was a postdoctoral fellow in the lab of Ali H. Brivanlou at The Rockefeller University studying the signaling pathways that maintain pluripotency and control neural induction in hESCs (human embryonic stem cells). He received his Ph.D. from the Medical College of Georgia and his B.S. and M.S. from the University of Arkansas at Fayetteville. He has also been appointed an Adjunct Associate Research Scientist in Pediatrics and Molecular Genetics at Columbia University.

Related Research:

Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD Sam Gandy Scott Noggle 2014-12-03 Stem Cell Consortium Doo Yeon Kim Kevin Eggan Marc Tessier-Lavigne Sam Gandy Scott Noggle Tamir Ben-Hur 2013-03-19

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD 2014

$200,000
Stem Cell Consortium 2013

$600,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Sproul, A. A., Vensand, L. B., Dusenberry, C. R., Jacob, S., Vonsattel, J. P., Paull, D. J., Shelanski, M. L., Crary, J. F., & Noggle, S. A. Generation of iPSC lines from archived non-cryoprotected biobanked dura mater, Acta Neuropathologica Communications, January 7, 2014, Read More

Nestor, M. W., Jacob, S., Sun, B., Prè, D., Sproul, A. A., Hong, S. I., Woodard, C., Zimmer, M., Chinchalongporn, V., Arancio, O., & Noggle, S. A. Characterization of a subpopulation of developing cortical interneuons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology-Cell Physiology, November 12, 2014, Read More

Prè, D., Nestor, M. W., Sproul, A. A., Jacob, S., Koppensteiner, P., Chinchalongporn, V., Zimmer, M., Yamamoto, A., Noggle, S. A., & Arancio, O. A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs), PLoS One, July 29, 2014, Read More

Sproul, A. A., Jacob, S., Pre, D., Kim, S. H., Nestor, M. W., Navarro-Sobrino, M., Santa-Maria, I., Zimmer, M., Aubry, S., Steele, J. W., Kahler, D. J., Dranovsky, A., Arancio, O., Crary, J. F., Gandy, S., & Noggle, S. A. Characterization and molecular profiling of PSEN1 familial Alzheimer’s disease iPSC-derived neural progenitors, PLoS One, January 8, 2014, Read More

Paquet, D., Kwart, D., Chen, A., Sproul, A., Jacob, S., Teo, S., Olsen, K. M., Gregg, A., Noggle, S., & Tessier-Lavigne, M. Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, April 27, 2016, Read More

Moreno, C. L., Della Guardia, L., Shnyder, V., Ortiz-Virumbrales, M., Kruglikov, I., Zhang, B., Schadt, E. E., Tanzi, R. E., Noggle, S., Buettner, C., & Gandy, S. iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling, Molecular Neurodegeneration, June 26, 2018, Read More

Ortiz-Virumbrales, M., Moreno, C. L., Kruglikov, I., Marazuela, P., Sproul, A., Jacob, S., Zimmer, M., Paull, D., Zhang, B., Schadt, E. E., Ehrlich, M. E., Tanzi, R. E., Arancio, O., Noggle, S., & Gandy, S. CRISPR/Cas9- Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN (N141l) neurons, Acta Neuropathologica Communications, October 27, 2017, Read More

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