Zhen Zhao, Ph.D.

Assistant Professor of Research Physiology & Biophysics
Keck School of Medicine of USC
Zilkha Neurogenetic Institute


Funded Research

Project Description Researchers Funding
The Role of PICALM Mutations in Alzheimer’s Disease

The search for biological understanding of Alzheimer’s disease (AD) has expanded to include new risk factors, particularly genes. Thanks to breakthroughs in human genetics and high-throughput genome sequencing, PICALM, the gene encoding phosphatidylinositol binding clathrin assembly protein, has been identified as a new risk gene for AD. As a key player in clathrin-mediated endocytosis and intracellular trafficking, PICALM critically regulates amyloid beta brain metabolism and neuronal toxicity.

2015 to 2017