These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Cellular and Molecular Studies of Apolipoprotein E Regulation of Blood-Brain Barrier, Synaptic and Neuronal Functions and Protection Strategies in Mouse Models With and Without Alzheimer’s Pathology |
2021, 2023 $500,000 |
|
Molecular Signatures of APOE-Mediated Blood-Brain Barrier Dysfunction Causing Neuronal and Synaptic Dysfunction |
2019-2020 $595,000 |
|
PICALM Gene Therapy and Drug Screening for Amyloid Beta Clearance (Year 3) |
2018 $300,000 |
|
The Role of PICALM Mutations in Alzheimer’s Disease |
2015, 2017, 2018 $645,000 |
|
PICALM Gene Therapy and Drug Screening for Abeta Clearance |
2015, 2016 $600,170 |
|
The role of PICALM in vascular clearance of amyloid-B and neuronal injury |
2014 $250,000 |
|
The Role of PICALM in Vascular Clearance of Amyloid Beta |
2012 100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration, October 19, 2018, Read More
Kisler, K., Sagare, A. P., Lazic, D., Bazzi, S., Lawson, E., Hsu, C. J., Wang, Y., Ramanathan, A., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier, Molecular Neurodegeneration, January 27, 2023, Read More
Zhao, Z., & Zlokovic, B. V. Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma?, Cell Reports Medicine, December 21, 2021, Read More
Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. Prion Protein Antagonists Rescue Alzheimer’s Amyloid-Beta Related Cognitive Deficits, Trends in Molecular Medicine, February 1, 2019, Read More
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews, January 1, 2019, Read More
Zhao, Z., & Zlokovic, B. V. Endothelial Tip Cell Finds Its Way with Piezo1, Neuron, October 14, 2020, Read More
Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo, Frontiers in Aging Neuroscience, April 29, 2020, Read More
Zhao, Z., & Zlokovic, B. V. Therapeutic TVs for Crossing Barriers in the Brain, Cell, July 23, 2020, Read More
Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., … Zlokovic, B. V. Vascular dysfunction — The disregarded partner of Alzheimer’s disease, Alzheimer's & Dementia, January 1, 2019, Read More
Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia, December 8, 2022, Read More
Barisano, G., Kisler, K., Wilkinson, B., Nikolakopoulou, A. M., Sagare, A. P., Wang, Y., Gilliam, W., Huuskonen, M. T., Hung, S. T., Ichida, J. K., Gao, F., Coba, M. P., & Zlokovic, B. V. A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice, Journal of Experimental Medicine, August 30, 2022, Read More
Zlokovic, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S., McKee, A., Snyder, H., Greenberg, S. M., Yaffe, K., Schaffer, C. B., Yuan, C., Hughes, T. M., Daemen, M. J., Williamson, J. D., González, H. M., Schneider, J., Wellington, C. L., Katusic, Z. S., Stoeckel, L., Koenig, J. I., Corriveau, R. A., Fine, L., Galis, Z. G., Reis, J., Wright, J.D., & Chen, J. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop, Alzheimer's & Dementia, October 8, 2020, Read More
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders, Nature Reviews Neurology, March 1, 2018, Read More
Kisler, K., Lazic, D., Sweeney, M. D., Plunkett, S., El Khatib, M., Vinogradov, S. A., Boas, D. A., Sakadži, S., & Zlokovic, B. V. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain, Nature Protocols, March 1, 2018, Read More
Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. The role of brain vasculature in neurodegenerative disorders, Nature Neuroscience, October 1, 2018, Read More
Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D'Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Chui, H. C., Law, M., Toga, A. W., & Zlokovic, B. V. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction, Nature Medicine, January 1, 2019, Read More
Kisler, K., Nikolakopoulou, A. M., & Zlokovic, B. V. Microglia have a grip on brain microvasculature., Nature Communications, September 6, 2021, Read More
Barisano, G., Montagne, A., Kisler, K., Schneider, J. A., Wardlaw, J. M., & Zlokovic, B. V. Blood–brain barrier link to human cognitive impairment and Alzheimer’s disease, Nature Cardiovascular Research, February 7, 2022, Read More
Montagne, A., Nikolakopoulou, A. M., Huuskonen, M. T., Sagare, A. P., Lawson, E. J., Lazic, D., Rege, S. V., Grond, A., Zuniga, E., Barnes, S. R., Prince, J., Sagare, M., Hsu, C. J., LaDu, M. J., Jacobs, R. E., & Zlokovic, B. V. APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β, Nature Aging, June 14, 2021, Read More
Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D'Orazio, L. M., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Reiman, E. M., Caselli, R. J., Chui, H. C., TCW, J., Chen, Y., Pa, J., Conti, P. S., Law, M., Toga, A.W., & Zlokovic, B. APOE4 Leads to Blood-Brain Barrier Dysfunction Predicting Cognitive Decline, Nature, April 29, 2020, Read More
Martinez, A. E., Weissberger, G., Kuklenyik, Z., He, X., Meuret, C., Parekh, T., Rees, J. C., Parks, B. A., Gardner, M. S., King, S. M., Collier, T. S., Harrington, M. G., Sweeney, M. D., Wang, X., Zlokovic, B. V., Joe, E., Nation, D. A., Schneider, L. S., Chui, H. C., Barr, J. R., Han, S.D., Krauss, R.M., & Yassine, H. N. The small HDL particle hypothesis of Alzheimer’s disease, Alzheimer's & Dementia, April 13, 2022, Read More
Huuskonen, M. T., Barisano, G., Chakhoyan, A., & Zlokovic, B. V. Editorial for “MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure”, Journal of Magnetic Resonance Imaging, July 31, 2021, Read More
Huuskonen, M. T., Kisler, K., Sagare, A. P., & Zlokovic, B. V. On the intersection between systemic infection, brain vascular dysfunction and dementia, Brain, May 11, 2021, Read More