The activities of the Michigan Alzheimer’s Disease Center seek to explore the neurobiological basis of dementia in African Americans, an understudied population. These research efforts intend to uncover fundamental knowledge about biomarkers of cognitive impairments. The focus of this research will be to determine whether vascular dysfunction and increased amyloid and/or tau deposition have independent or synergistic effects on cognition. The information obtained will be used to design both novel pharmacological and nonpharmacological interventions. This study intends to provide information about targeted enrollment for interventions of this nature.