Neurobiological Basis of Cognitive Impairment in African Americans: Deep Phenotyping of Older African Americans at Risk of Dementia—The Dementia (in) African American Population Phenotyping (for) Potential Elevated Risk (DAAPPER) Study

2018, 2022

This proposal will leverage activities of the Michigan Alzheimer’s Disease Center to explore the neurobiological basis of dementia in African Americans, an understudied population about which we still lack fundamental knowledge regarding biomarkers of cognitive impairment. Through these studies, we hope to determine whether vascular compromise and increased amyloid and/or tau deposition have unique or synergistic effects on cognition. This information may be crucial in designing new pharmacological and nonpharmacological interventions, and in providing important information about targeted enrollment for such interventions.

Funding to Date



Biomarkers/Diagnostics/Studies of Risk & Resilience, Foundational


Henry Paulson, M.D., Ph.D.

Benjamin M. Hampstead, Ph.D., ABPP/CN

Bruno Giordani, Ph.D.

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