Defining the Effects of Physiological Synaptic Activity on Abeta Levels: Implications for AD


The objective of this proposal is to determine the effect of physiological alterations in neuronal activity on ISF Aβ levels in vivo. Such information may provide important information as to how to potentially regulate the probability of whether or not Aβ will or will not ultimately aggregate in the brain and initiate the process we know of as AD. We will utilize in vivo microdialysis with concurrent electrophysiological recordings to determine how physiological changes in neuronal activity dynamically affects ISF Aβ.

Funding to Date



Studies of APP and Abeta, Translational


David Holtzman, M.D.