2024
Myelin, a structure essential to neuronal health, is defective in Alzheimer’s Disease (AD), and myelin impairment can precipitate neurodegeneration. This proposal is aimed at characterizing the impact of DNA damage and downstream signaling in oligodendrocytes in AD. Based on our preliminary evidence, genotoxic stress and homeostatic disruption of oligodendrocytes in AD may be responsible for the myelin defects, thus spurring and perhaps precipitating neuronal decline. Our proposed aims could identify new therapeutic targets in oligodendrocytes, an overlooked cell type that is vital to neuronal health and potentially pivotal for disease progression.
Alban Gaultier, Ph.D.
