Joseph Castellano, Ph.D., is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai and core member of the Ronald M. Loeb Center for Alzheimer’s disease. His laboratory focuses on the role of aging and genomic variation in perturbing communication between the systemic and central nervous system compartments in Alzheimer’s disease. His work led to the identification of youth-associated plasma factors that regulate extracellular matrix turnover in the hippocampus, affecting neuroimmune function and synaptic plasticity.

By bridging insights from the fields of neurodegeneration, immunology, and aging, Dr. Castellano’s group is working to identify novel strategies that harness brain resilience and develop novel strategies to target Alzheimer’s disease across the lifespan. His research program integrates basic, translational, and systems-level approaches, including parabiosis, microdialysis, proteomics, and transcriptomic approaches in model organisms to understand how signals are integrated in the extracellular space to affect cross-cellular communication in the setting of Alzheimer’s disease pathology.

To learn more, follow Dr. Castellano at @JM_Castell and @jmcastell.bsky.social, as well as the Sinai Friedman Brain Institute at @SinaiBrain.