These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Chronic Viral Neuroinfection Mediates Amyloid Beta Deposition in Transgenic Alzheimer’s Disease Mice |
2017 $350,000 |
|
Abeta Expression Protects the Brain from Herpes Simplex Virus |
2015 to 2016 $500,000 |
|
Role of the Gut Microbiome in AD Pathology and the Potential of Probiotic Therapeutic Strategies |
2015 $150,000 |
|
Potential for Host Cytotoxicity from Microbially-derived Abeta Oligomers |
2009 $250,000 |
|
Identification of Agents that Inhibit the Generation and Neurotoxicity of Cross-linked B-amyloid Protein Species |
2006 $200,000 |
|
Investigation of Certain Properties of Mitochondria Membranes Related to AD |
2008 $200,000 |
|
The Amylin Protein of Diabetes Mellitus is an Antimicrobial Peptide |
2010 $1,600,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
William A. Eimer,1,2 Deepak Kumar Vijaya Kumar,1,2 Nanda Kumar Navalpur Shanmugam,Alex S. Rodriguez, Teryn Mitchell, Kevin J. Washicosky, Bence Gyorgy, Xandra O. Breakefield, Rudolph E. Tanzi, and Robert D. Moir Alzheimer’s Disease-Associated b-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection, Neuron (Cell), July 11, 2018, Read More
Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5), 7 Sep 2016, 345–348, Read More
B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD Role of common and rare APP DNA sequence variants in Alzheimer disease, Neurology 78, 78/16, April 17, 2012, 1250-1257, Read More
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity., Human Molecular Genetics, Vol 18, Oct 15, 2009, Read More
Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels, Archives of Neurology, Vol. 66 No. 5, May 2009, Read More
Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64, Dec 2008, Read More
Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18), May 2, 2008, 11866-75, Read More
Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE. The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation., J. Neurosci., 27, 2/7/2007, 1247-1254, Read More