These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Chronic Viral Neuroinfection Mediates Amyloid Beta Deposition in Transgenic Alzheimer’s Disease Mice |
2017 $350,000 |
|
Amyloid Beta Expression Protects the Brain from Herpes Simplex Virus |
2015, 2016 $500,000 |
|
Role of the Gut Microbiome in AD Pathology and the Potential of Probiotic Therapeutic Strategies |
2015 $150,000 |
|
Identification of Agents that Inhibit the Generation and Neurotoxicity of Cross-linked B-amyloid Protein Species |
2006, 2007 $200,000 |
|
Investigation of Certain Properties of Mitochondria Membranes Related to AD |
2008 $200,000 |
|
The Amylin Protein of Diabetes Mellitus is an Antimicrobial Peptide |
2010, 2012, 2013 $900,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology, November 11, 2008, Read More
Moir, R. D., Lathe, R., & Tanzi, R. E. The Antimicrobial protection hypothesis of Alzheimer’s disease, Alzheimer's & Dementia, October 9, 2018, Read More
Moir, R. D., & Tanzi, R. E. Low Evolutionary Selection Pressure in Senescence does not explain the persistence of amyloid-beta in the vertebrate genome, Frontiers in Aging Neuroscience, March 28, 2019, Read More
Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., Moir, R. D., Becker, K. D., & Tanzi, R. E. Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity, Human Molecular Genetics, October 15, 2009, Read More
Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine, May 16, 2012, Read More
Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. Alzheimer’s disease beta-amyloid is rapidly seeded by herpesviridae to protet against brain infection, Neuron, July 11, 2018, Read More
Kumar, D. K., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., & Moir, R. D. Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Science Translational Medicine, May 25, 2016, Read More
Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One, March 3, 2010, Read More
Chakraborty, R., Vepuri, V., Mhatre, S. D., Paddock, B. E., Miller, S., Michelson, S. J., Delvadia, R., Desai, A., Vinokur, M., Melicharek, D. J., Utreja, S., Khandelwal, P., Ansaloni, S., Goldstein, L. E., Moir, R. D., Lee, J. C., Tabb, L. P., Saunders, A. J., & Marenda, D. R. Characterization of a Drosophila Alzheimer’s disease model: pharmacoogical rescue of cognitive defects, PLoS One, June 6, 2011, Read More