These projects were made possible from Cure Alzheimer's Fund support.
| Project Description | Researchers | Funding |
|---|---|---|
| Microbiome Consortium: Interaction of the Microbiome with Astrocytes and Amyloid Pathology |
2023, 2024 $690,000 |
|
| Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology |
2022, 2023 $572,804.65 |
|
| Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knock-in Mice |
2022 $246,804 |
|
| Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knockin Mice |
2020 $234,796 |
|
| Molecular and Cellular Mechanisms of ACE1 Variant in Alzheimer’s Disease |
2015, 2017, 2019 $1,000,000 |
|
| Investigations of the Mechanism of Action of TagretinR/Bexarotene on Amyloid Clearance in Transgenic Mouse Models |
2012 $50,343 |
|
| The roles of Eps homology domain (EHD) proteins and synaptic activity in axon transport of the Alzheimer’s Beta-secretase BACE1 in the brain |
2012, 2013 $200,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Jeon, S., Salvo, M. A., Alia, A. O., Popovic, J., Zagardo, M., Chandra, S., Nassan, M., Gate, D., Vassar, R., & Cuddy, L. K. Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging, Neurology of Disease, November 7, 2024, Read More
Chandra, S., & Vassar, R. J. Gut microbiome-derived metabolites in Alzheimer’s disease: Regulation of immunity and potential for therapeutics, Immunological Reviews, October 24, 2024, Read More
Chandra, S., & Vassar, R. The role of the gut microbiome in the regulation of astrocytes in Alzheimer’s disease, Neurotherapeutics, July 24, 2024, Read More
Yan, R., & Vassar, R. Targeting the beta secretase BACE1 for Alzheimer’s disease therapy, Lancet Neurology, February 17, 2014, Read More
Yan, R., Fan, Q., Zhou, J., & Vassar, R. Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease, Neuroscience & Behavioral Reviews, April 1, 2016, Read More
Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects, Journal of Neurochemistry, April 19, 2014, Read More
Sadleir, K. R., Kandalepas, P. C., Buggia-Prévot, V., Nicholson, D. A., Thinakaran, G., & Vassar, R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased amyloid beta generation in Alzheimer’s disease, Acta Neuropathologica, March 18, 2016, Read More
Buggia-Prévot, V., Fernandez, C. G., Riordan, S., Vetrivel, K. S., Roseman, J., Waters, J., Bindokas, V. P., Vassar, R., & Thinakaran, G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase, Molecular Neurodegeneration, January 4, 2014, Read More
Buggia-Prévot, V., Fernandez, C. G., Udayar, V., Vetrivel, K. S., Elie, A., Roseman, J., Sasse, V. A., Lefkow, M., Meckler, X., Bhattacharyya, S., George, M., Kar, S., Bindokas, V. P., Parent, A. T., Rajendran, L., Band, H., Vassar, R., & Thinakaran, G. A function for EHD family proteins in unidirectional retrograde dendritic transprt of BACE1 and Alzheimer’s disease Ab production, Cell Reports, December 26, 2013, Read More
Upadhyay, A., Chhangani, D., Rao, N. R., Kofler, J., Vassar, R., Rincon-Limas, D. E., & Savas, J. N. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity, Molecular Neurodegeneration, September 14, 2023, Read More
Alia, A. O., Jeon, S., Popovic, J., Salvo, M. A., Sadleir, K. R., Vassar, R., & Cuddy, L. K. Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models, Scientific Reports, December 21, 2022, Read More
Hur, J. Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Vassar, R., … Greengard, P., ... Li, Y. M. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease, Nature, September 2, 2020, Read More
McDade, E., Voytyuk, I., Aisen, P., Bateman, R. J., Carrillo, M. C., De Strooper, B., Haass, C., Reiman, E. M., Sperling, R., Tariot, P. N., Yan, R., Masters, C. L., Vassar, R., & Lichtenthaler, S. F. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease, Nature Reviews Neurology, September 21, 2021, Read More
Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine, September 30, 2020, Read More
