Professor in the Department of Molecular, Cellular, and Developmental Biology and the Department of Neurology, University of Michigan, Ann Arbor
Dr. Yanzhuang Wang is a Professor in the Department of Molecular, Cellular and Developmental Biology (MCDB) and the Department of Neurology at the University of Michigan, Ann Arbor. His research aims to understand how the stacked Golgi structure is formed, why its formation is important for Golgi functions, how it becomes defective in Alzheimer’s disease. Dr. Wang’s work establishes connections between Golgi structural defects and multiple pathologies observed in Alzheimer’s disease, including elevated Aβ production, aberrant protein glycosylation, compromised lysosomal and autophagosomal degradation, and activation of microglia. Consequently, his overarching objective is to develop molecular tools capable of stabilizing Golgi structure and function, thereby potentially slowing down the progression of the disease.
