Cure Alzheimer's Fund Cure Alzheimer's Fund

Paola Pizzo, Bc.S, Ph.D.

Associate Professor of General Pathology, University of Padova, Italy

Dr. Paola Pizzo got her Bc.S. in Biology at the University of Padova in 1988. She did her Ph.D. in Experimental Pathology at the same University, with Prof. Francesco Di Virgilio, investigating the new role of ATP as an extracellular signaling molecule. She then moved to Israel for her post-doc at the Weizmann Institute of Science, in the lab of Profs. David Yaffe and Uri Nudel, working on DP71, a new dystrophin gene product. Back to Padova as Assistant Professor, she worked together with Prof. Tullio Pozzan, defining the role of different pathways of cellular Ca2+ homeostasis in multiple physiological and pathological conditions. In 2000, she started her own project on Ca2+ handling alterations and mitochondria dysfunction in familial Alzheimer’s disease (FAD), unraveling the role of mutated FAD-linked presenilin 2 and its impact on neuronal metabolism and function.

 

Related Research:

Extracellular ATP is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation Paola Pizzo Anna Lisa Giuliani Francesco Di Virgilio 2024-01-11 Extracellular ATP Is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation Paola Pizzo Francesco Di Virgilio 2022-02-15

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Extracellular ATP is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation 2023, 2024

$299,994.50
Extracellular ATP Is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation 2021, 2022

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Maioli, S., Nalvarte, I., Ankarcrona, M., Schultzberg, M., Zuloaga, K. L., Goikolea, J., Visser, P. J., De Strooper, B., Winblad, B., Pizzo, P., Williams, P. A., Rodriguez-Rodriguez, P., & Naia, L. Bioenergetics and lipid metabolism in Alzheimer’s disease: From cell biology to systemic health, Journal of Internal Medicine, November 6, 2025, Read More

Azarnia Tehran, D., & Pizzo, P. The complex web of membrane contact sites in brain aging and neurodegeneration, Cellular and Molecular Life Sciences, August 8, 2025, Read More

García Casas, P., Rossini, M., Påvénius, L., Saeed, M., Arnst, N., … Pizzo, P., & Filadi, R. Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters, Nature Communications, November 12, 2024, Read More

Filadi, R., & Pizzo, P. Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome, Cell Calcium, September 12, 2024, Read More

Arnst, N., Redolfi, N., Lia, A., Bedetta, M., Greotti, E., & Pizzo, P. Mitochondrial Ca2+ Signaling and Bioenergetics in Alzheimer’s Disease, Biomedicines, November 24, 2022, Read More

Garcia-Casas, P., Rossini, M., Filadi, R., & Pizzo, P. Mitochondrial Ca2+ signaling and Alzheimer’s disease: Too much or too little?, Cell Calcium, May 11, 2023, Read More

Filadi, R., & Pizzo, P. Key Signalling Molecules in Aging and Neurodegeneration, Cells, February 28, 2022, Read More

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