These projects were made possible from Cure Alzheimer's Fund support.
| Project Description | Researchers | Funding |
|---|---|---|
| Investigating the Association Between Clonal Hematopoiesis and Alzheimer’s Disease |
2024 $201,250 |
|
| Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD |
2021, 2023 $345,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Kiss, M. G., Cohen, O., McAlpine, C. S., & Swirski, F. K. Influence of sleep on physiological systems in atherosclerosis, Nature Cardiovascular Research, November 8, 2024, Read More
Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Ferreira da Silva, J., … McAlpine, C. S. Myocardial infarction augments sleep to limit cardiac inflammation and damage, Nature, October 30, 2024, Read More
Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A. C., & Sokol, C. L. A γδ T cell–IL-3 axis controls allergic responses through sensory neurons, Nature, September 4, 2024, Read More
Gerhardt, T., Huynh, P., & McAlpine, C. S. Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis, Cardiovascular Research, August 1, 2024, Read More
Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity, May 8, 2023, Read More
Yates, A. G., Khamhoung, A., & McAlpine, C. S. Interleukin-3 gets a fresh start in the brain, Genes & Immunity, December 8, 2023, Read More
McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine, September 21, 2022, Read More
Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity, February 23, 2023, Read More
Cohen, O., Shah, N. A., & McAlpine, C. S. Sleep calibrates atherosclerotic cardiovascular disease, Nature Cardiovascular Research, December 7, 2022, Read More
McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More
