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Tal Nuriel, Ph.D.

Dr. Nuriel is an Assistant Professor at the Columbia University Medical Center in the department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer’s disease and the Aging Brain. Dr. Nuriel received his Ph.D. from the Weill Cornell Graduate School for Medical Sciences in 2013, where his thesis work involved the use of mass spectrometry to investigate the ability of nitrosative and oxidative stress to modify proteins during numerous disease states. After completing his thesis work, Dr. Nuriel joined the laboratory of Dr. Karen Duff, a recognized leader in the Alzheimer’s field. Dr. Nuriel’s primary focus in the laboratory is the use of multi-omics platforms (transcriptomics, lipidomics and metabolomics) to study the role of APOE4 in the development of Alzheimer’s disease. These studies have led to intriguing new areas of investigation on APOE4 and Alzheimer’s disease, including the current study funded by Cure Alzheimer’s Fund.

Related Research:

Investigating the Mechanism of APOE4-associated Neuronal Hyperactivity in the Entorhinal Cortex and its Effect on Tauopathy Propagation Karen Duff Tal Nuriel 2018-08-27 Investigating the Mechanism of Entorhinal Cortex Hypermetabolism in APOE4 Targeted Replacement Mice Karen Duff Tal Nuriel 2016-05-12

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Investigating the Mechanism of APOE4-associated Neuronal Hyperactivity in the Entorhinal Cortex and its Effect on Tauopathy Propagation 2017

$200,000
Investigating the Mechanism of Entorhinal Cortex Hypermetabolism in APOE4 Targeted Replacement Mice 2016

$150,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., Dillman, A. A., Figueroa, H. Y., Cookson, M. R., Gross, S. S., Fraenkel, E., Duff, K. E., & Nuriel, T. APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice, Scientific Reports, March 9, 2020, Read More

Miranda, A. M., Ashok, A., Chan, R. B., Zhou, B., Xu, Y., McIntire, L. B., Area-Gomez, E., Di Paolo, G., Duff, K. E., Oliveira, T. G., & Nuriel, T. Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice, Translational Psychiatry, March 29, 2022, Read More

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