The SAMP8 mouse model line is a model of accelerated senescence, and interestingly, develops sparse amyloid plaques, which is remarkable given the less amyloidogeneic properties of murine Aß. Hence, the research hypothesis for this project is that by introducing the more amyloidogenic human APP at the endogenous locus, researchers will be able to more robustly mimic the onset of sporadic Alzheimer’s disease, and thereby utilize this model for pre-clinical development and for widespread distribution to other investigators in the field.
