Some individuals harbor in the brain burdens of plaques and tangles at autopsy similar to those found in typical demented Alzheimer’s patients, which would be expected to have had devastating clinical consequences, but never developed dementia during their lifetime, indicating “resilience”. This project aims to identify the neuropathological, cellular, and molecular mediators of this remarkable phenomenon. Understanding the mechanisms of human brain resilience to Alzheimer’s pathology may prove critical to inform the development of novel cognitive–sparing therapies for Alzheimer’s and better predictive biomarkers of individual cognitive fate.
