These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Dissecting Microglial State Dynamics in Alzheimer’s Disease |
2024 $300,000 |
|
CIRCUITS: Dissecting Microglial State Dynamics in Alzheimer’s Disease |
2023 $300,000 |
|
CIRCUITS: Consortium to Infer Regulatory Circuits and Uncover Innovative Therapeutic Strategies—Production Group |
2020, 2021 $1,100,000 |
|
CIRCUITS: Production Center for Reference and Variation Gene-Regulatory Maps |
2016, 2019 $1,500,000 |
|
CIRCUITS: Functional Analysis of Alzheimer’s Disease Risk Genes Using Human-Induced Pluripotent Stem Cells |
2016 and 2018 $860,000 |
|
Studying the Functional Consequences of Alzheimer’s Disease Risk Variants in the CLU and ABCA7 Genes Using Both Human and Mouse Models |
2015, 2016 $500,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., Band, N., James, B. T., Babu, S., Galiana-Melendez, F., Louderback, K., Prokopenko, D., Tanzi, R. E., Bennett, D. A., Tsai, L. H., & Kellis, M. Single-cell multiregion dissection of Alzheimer’s disease, Nature, July 24, 2024, Read More
10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More
Fan, Q., Gayen, M., Singh, N., Gao, F., He, W., Hu, X., Tsai, L. H., & Yan, R. The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology, Journal of Experimental Medicine, June 17, 2019, Read More
Singh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., Hu, X., & Yan, R. BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1, Science Advances, June 17, 2022, Read More
Barker, S. J., Raju, R. M., Milman, N. E. P., Wang, J., Davila-Velderrain, J., Gunter-Rahman, F., Parro, C. C., Bozzelli, P. L., Abdurrob, F., Abdelaal, K., Bennett, D. A., Kellis, M., & Tsai, L. H. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration, Science Translational Medicine, November 3, 2021, Read More
Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., & Tsai, L. H. Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble, Nature Neuroscience, October 5, 2020, Read More
Blanchard, J. W., Bula, M., Davila-Velderrain, J., Akay, L. A., Zhu, L., Frank, A., Victor, M. B., Bonner, J. M., Mathys, H., Lin, Y. T., Ko, T., Bennett, D. A., Cam, H. P., Kellis, M., & Tsai, L. H. Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes, Nature Medicine, June 8, 2020, Read More
Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., Martorell, A. J., Ransohoff, R. M., Hafler, B. P., Bennett, D. A., Kellis, M., & Tsai, L. H. Single-Cell Transcriptomic Analysis of Alzheimer’s Disease, Nature, May 1, 2019, Read More
Sun, N., Victor, M. B., Park, Y. P., Xiong, X., Scannail, A. N., Leary, N., Prosper, S., Viswanathan, S., Luna, X., Boix, C. A., James, B. T., Tanigawa, Y., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. Human microglial state dynamics in Alzheimer’s disease progression, Cell, September 28, 2023, Read More
Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., Kellis, M., & Tsai, L. H. Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration, Cell, September 28, 2023, Read More
Xiong, X., James, B. T., Boix, C. A., Park, Y. P., Galani, K., Victor, M. B., Sun, N., Hou, L., Ho, L. L., Mantero, J., Scannail, A. N., Dileep, V., Dong, W., Mathys, H., Bennett, D. A., Tsai, L. H., & Kellis, M. Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion, Cell, September 28, 2023, Read More
Mathys, H., Peng, Z., Boix, C. A., … Kellis, M. & Tsai, L. H. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology, Cell, September 28, 2023, Read More
Garcia, F. J., Sun, N., Lee, H., Godlewski, B., Mathys, H., Galani, K., Zhou, B., Jiang, X., Ng, A. P., Mantero, J., Tsai, L. H., Bennett, D. A., Sahin, M., Kellis, M., & Heiman, M. Single-cell dissection of the human brain vasculature, Nature, February 14, 2022, Read More
Udeochu, J. C., Amin, S., … Tsai, L. H., Subhash, S. C., & Gan, L. Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience, Nature Neuroscience, April 24, 2023, Read More
Sun, N., Akay, L. A., Murdock, M. H., Park, Y., Galiana-Melendez, F., Bubnys, A., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease., Nature Aging, June 1, 2023, Read More
Ramamurthy, E., Welch, G., Cheng, J., Yuan, Y., Gunsalus, L., Bennett, D. A., Tsai, L. H., & Pfenning, A. R. Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics, Frontiers in Molecular Neuroscience, January 6, 2023, Read More
Lin, Y. T., Seo, J., Gao, F., Feldman, H. M., Wen, H. L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., Rueda, R., Kritskiy, O., Abdurrob, F., Peng, Z., Milo, B., Yu, C. J., Elmsaouri, S., Dey, D., Ko, T., Yankner, B. A., … Tsai, L. H. APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types., Neuron, June 27, 2018, Read More
Murdock, M. H., & Tsai, L. H. Insights into Alzheimer’s disease from single-cell genomic approaches, Nature Neuroscience, January 2, 2023, Read More
Canter, R. G., Penney, J., & Tsai, L. H. The road to restoring neural circuits for the treatment of Alzheiemer’s disease, Nature, November 10, 2016, Read More
Penney, J., Ralvenius, W. T., & Tsai, L. H. Modeling Alzheimer’s Disease With iPSC-derived Brain Cells, Molecular Psychiatry, August 7, 2019, Read More
Penney, J., Ralvenius, W. T., Loon, A., Cerit, O., Dileep, V., Milo, B., Pao, P. C., Woolf, H., & Tsai, L. H. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss, Glia, November 15, 2023, Read More
Akay, L. A., Effenberger, A. H., & Tsai, L. H. Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function, Genes & Development, February 1, 2021, Read More
Dileep, V., & Tsai, L. H. Three-dimensional chromatin organization in brain function and dysfunction, Current Opinion in Neurobiology, June 7, 2021, Read More
Watson, L. A., & Tsai, L. H. In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, December 23, 2017, Read More
Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., Cerit, O., Wen, H. L., Liu, L., Welch, G., Bonner, M., & Tsai, L. H. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity, Cell Stem Cell, August 4, 2022, Read More
Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K. H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y. T., Su, S. C., Church, G. M., Tsai, L. H., & Yankner, B. A. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease, Cell Reports, January 29, 2019, Read More
Grossman, N., Bono, D., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H. J., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L. H., Pascual-Leone, A., & Boyden, E. S. Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, June 1, 2017, Read More
Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., … Kellis, M., Tsai, L. H. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes, Nature, November 16, 2022, Read More
Paolicelli, R. C., Sierra, A., Stevens, B., et al. Microglia states and nomenclature: A field at its crossroads, Neuron, November 2, 2022, Read More
Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., Leary, N. S., Pfenning, A. R., Kellis, M., & Tsai, L. H. Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration, Science Advances, September 28, 2022, Read More