Alzheimer’s disease causes memory loss, disrupted sleep, and changes in brain activity that worsen over time. During deep sleep, the healthy brain produces slow waves that help form memories, but these slow waves are impaired in Alzheimer’s disease.
Our research explores whether stem-cell therapy can restore these brain rhythms and slow disease progression. By transplanting specialized neuronal precursors called inhibitory interneuron progenitors into the brains of mice with Alzheimer’s-like disease, we aim to rebalance overactive brain circuits, improve sleep rhythms, and enhance memory. Using advanced imaging and light-based techniques, we will test mouse and human stem-cell derived cells to see how well they restore healthy brain function. This work could lay the foundation for developing new treatments that target the root causes of Alzheimer’s rather than just its symptoms.
