2008
We have identified myelin basic protein (MBP) as a novel factor in brain that can bind Abeta and potently inhibit its assembly into fibrils. In light of this novel finding the overall hypothesis of this proposal is that defined fragments of MBP can regulate Abeta assembly and modulate its cytotoxic properties. This will provide the basis for developing novel and potent Abeta assembly inhibitors.
$100,000
Studies of APP and Abeta, Translational
William Van Nostrand, Ph.D.
Jaehong Suh, Ph.D., | 2024
William C. Mobley, | 2023
William Van Nostrand, | 2023
Meytal Landau, | 2022
Caleb Finch, Michael A. Bonaguidi, | 2021
Raja Bhattacharyya, Rudy Tanzi, | 2021
Gentry Patrick, | 2020
William C. Mobley, Lucía Chávez-Gutiérrez, | 2018