We have identified myelin basic protein (MBP) as a novel factor in brain that can bind Abeta and potently inhibit its assembly into fibrils. In light of this novel finding the overall hypothesis of this proposal is that defined fragments of MBP can regulate Abeta assembly and modulate its cytotoxic properties. This will provide the basis for developing novel and potent Abeta assembly inhibitors.
Studies of APP and Abeta, Translational
William Van Nostrand, Ph.D.
William Van Nostrand, | 2023
Meytal Landau, | 2022
Caleb Finch, Michael A. Bonaguidi, | 2021
Raja Bhattacharyya, Rudy Tanzi, | 2021
Gentry Patrick, | 2020
William C. Mobley, Lucía Chávez-Gutiérrez, | 2018
Roberto Malinow, | 2018
Tae-Wan Kim, | 2017