Cure Alzheimer's Fund Cure Alzheimer's Fund

Development of Tau Microdialysis as a Method to Study Tau Metabolism, Pathophysiology and Response to Treatment

2009

The hypothesis of this proposal is that a method can be developed to measure tau levels in the extracellular space of the brain (interstitial fluid–ISF) and that assessment of ISF tau in both normal mice as well as a variety of animal models that develop AD pathology will provide new insights into tau metabolism and the relationship between Aβ and tau in AD. If this method development is successful, it has a chance to tell us more about the pathophysiology of AD as well as a provide a novel way to screen for new AD treatments.

David Holtzman Studies of Tau Translational

Funding to Date

$100,000

Focus

Studies of Tau, Translational

Researchers

David Holtzman, M.D.

Related Content:


Selective Vulnerability in Posterior Cortical Atrophy John R. Dickson Bradley T. Hyman 2024-11-21 APOE Consortium: Investigating Potential Cell Autonomous Neuroprotection of APOE Protective Variants David Holtzman 2024-11-20 2024 Jeffrey L. Morby Prize for Exceptional Research David Holtzman 2024-07-03 Hypertension, Tau, and Neurodegeneration Costantino Iadecola Giuseppe Faraco 2024-06-28 Non-Invasive Delivery of IL-2 to the CNS for Local Expansion of Regulatory T Cells and Prevention of Neurodegeneration in Tauopathy Peter M. Tessier David Holtzman 2024-06-26 Modulating the Levels of Tau-Seed Interactors to Treat Alzheimer’s Disease Cristian Lasagna-Reeves 2024-05-29 Cellular Vulnerability to Pathological Tau Protein Accumulation in Alzheimer’s Disease Mathieu Bourdenx Karen Duff 2024-03-18 Investigating the Role of Tau Protein in Neuronal Senescence Miranda Orr 2024-01-12