Patient-Based Structural and Functional Biology of Tauopathies


We seek to generate models depicting the unique structures characteristic of abnormal forms of tau protein that accumulate in Alzheimer’s disease and related disorders. In addition, using new structural models, we have generated novel resources to provide both a greater understanding of key events that drive disease, as well as facilitated testing of potential therapies.

Funding to Date



Studies of Tau, Translational


Leonard Petrucelli, Ph.D.