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Cameron McAlpine, Ph.D.

Assistant Professor, Cardiovascular Research Institute and the departments of Medicine and Neuroscience at the Icahn School of Medicine at Mount Sinai

Dr. Cameron McAlpine is an assistant professor in the Cardiovascular Research Institute and the departments of Medicine and Neuroscience at the Icahn School of Medicine at Mount Sinai. Dr. McAlpine joined Mount Sinai and opened his independent lab in June 2021 after completing a postdoc at the Massachusetts General Hospital in Boston under the supervision of Dr. Filip Swirski. Dr. McAlpine’s research has focused on uncovering the biological pathways that connect sleep to immune function and Alzheimer’s disease. His laboratory uses multidisciplinary approaches to explore long-rage interorgan communication and leukocyte function to better understand how behavioral and lifestyle factors influence the immune system and chronic age-related neurodegenerative diseases.

@cam_phd

https://labs.icahn.mssm.edu/mcalpinelab/

Related Research:

Investigating the Association Between Clonal Hematopoiesis and Alzheimer’s Disease Cameron McAlpine 2024-02-28 Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD Cameron McAlpine Filip Swirski 2022-02-15

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Investigating the Association Between Clonal Hematopoiesis and Alzheimer’s Disease 2024

$201,250
Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD 2021, 2023

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity, May 8, 2023, Read More

Yates, A. G., Khamhoung, A., & McAlpine, C. S. Interleukin-3 gets a fresh start in the brain, Genes & Immunity, December 8, 2023, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine, September 21, 2022, Read More

Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity, February 23, 2023, Read More

Cohen, O., Shah, N. A., & McAlpine, C. S. Sleep calibrates atherosclerotic cardiovascular disease, Nature Cardiovascular Research, December 7, 2022, Read More

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