Erin H. Norris, Ph.D.

Dr. Norris received her PhD in Pharmacological Sciences from the University of Pennsylvania in 2004.  Her dissertation, which investigated post-translational modifications of alpha-synuclein protein and their effects on the pathogenesis of Parkinson’s disease and other synucleinopathies, was conducted under the mentorship of Dr. Virginia M.-Y. Lee.

After leaving Philadelphia, Dr. Norris began her postdoctoral work under the direction of Dr. Sidney Strickland in the Laboratory of Neurobiology & Genetics at The Rockefeller University in New York City. She initially studied the role of tissue plasminogen activator (tPA) – the clot-busting enzyme that can be beneficial in the event of a heart attack or ischemic stroke – in anxiety, drug addiction, and fetal alcohol syndrome. Over the years, her focus shifted to exploring the effects of vascular dysfunction in Alzheimer’s disease pathogenesis and pathophysiology. Dr. Norris began running her own independent research group and was promoted to Research Assistant Professor in January 2017. She received the Biochemical Journal’s Young Investigator’s Award in 2005 and a career development award from the American Heart Association in 2014. She also served as Visiting Assistant Professor of Biology at Bard College in 2017.

In addition to her research responsibilities, Dr. Norris is an active admissions committee member for Rockefeller’s Summer Undergraduate Research Fellowship program and has served as an editorial board member for two scientific journals.

 

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Baker, S. K., Chen, Z. L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S. Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease, Proceedings of the National Academy of Sciences of the United States of America, September 25, 2018, Read More

Chen, Z. L., Singh, P., Wong, J., Horn, K., Strickland, S., & Norris, E. H. An antibody against HK blocks Alzheimer’s disease peptide beta-amyloid-induced bradykinin release in human plasma, Proceedings of the National Academy of Sciences of the United States of America, November 12, 2019, Read More

Cajamarca, S. A., Norris, E. H., van der Weerd, L., Strickland, S., & Ahn, H. J. Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen, Proceedings of the National Academy of Sciences of the United States of America, June 9, 2020, Read More

Chen, Z. L., Revenko, A. S., Singh, P., MacLeod, A. R., Norris, E. H., & Strickland, S. Depletion of coagulation factor XII ameliorates brain pathology and cogntive impairment in Alzheimer disease mice, Blood, May 4, 2017, Read More

Suidan, G. L., Singh, P. K., Patel-Hett, S., Chen, Z. L., Volfson, D., Yamamoto-Imoto, H., Norris, E. H., Bell, R. D., & Strickland, S. Abnormal clotting of the intrinsic contact pathway in Alzhiemer’s disease patients is related to cognitive ability, Blood Advances, April 26, 2018, Read More

Chen, Z. L., Singh, P. K., Horn, K., Strickland, S., & Norris, E. H. Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation, Blood Advances, May 24, 2022, Read More

Ahn, H. J., Chen, Z. L., Zamolodchikov, D., Norris, E. H., & Strickland, S. Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion in Hematology, September 1, 2017, Read More

Farfara, D., Feierman, E., Richards, A., Revenko, A. S., MacLeod, R. A., Norris, E. H., & Strickland, S. Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits, Glia, March 18, 2019, Read More

Singh, P. K., Chen, Z. L., Strickland, S., & Norris, E. H. Increased Contact System Activation in Mild Cognitive Impairment Patients with Impaired Short-Term Memory, Journal of Alzheimer's Disease, September 1, 2020, Read More

Baker, S. K., Chen, Z. L., Norris, E. H., & Strickland, S. Plasminogen mediates communication between the peripheral and central immune system during systemic immune challenge with lipopolysaccharide, Journal of Neuroinflammation, August 28, 2019, Read More

Singh, P. K., Chen, Z. L., Ghosh, D., Strickland, S., & Norris, E. H. Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer’s patients, Neurobiology of Disease, March 12, 2020, Read More

Berk-Rauch, H. E., Choudhury, A., Richards, A. T., Singh, P. K., Chen, Z. L., Norris, E. H., Strickland, S., & Ahn, H. J. Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease, Frontiers in Aging Neuroscience, March 9, 2023, Read More

Tataryn, N. M., Singh, V., Dyke, J. P., Berk-Rauch, H. E., Clausen, D. M., Aronowitz, E., Norris, E. H., Strickland, S., & Ahn, H. J. Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer’s Disease, Neurobiology of Aging, July 28, 2021, Read More