Cure Alzheimer's Fund Cure Alzheimer's Fund

Daniel Irimia, M.D., Ph.D.

Associate Professor in the Surgery Department at Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston

Dr. Irimia is a bioengineer, a researcher in the areas of microfluidics, and a medical doctor by training.  His work melds engineering and medicine, towards the development of novel microfluidic tools for a variety of applications, from the early diagnostic of sepsis and the study of neutrophil swarming to the stimulation of neuronal migration and quantification of axonal transport.  Dr. Irimia has published more than 100 journal articles in top-tier journals such as Nature Biomedical Engineering, Nature Materials, Nature Communications, the Proceedings of the National Academy of Sciences. He was recently awarded the “Pioneers of Miniaturization” prize from the Chemical and Biological Microsystems Society for his work on microfluidic devices for studying neutrophils in inflammation, infections, and sepsis.  He is the organizer of the Dicty World Race, a global effort aimed at encouraging biologists to integrate microfluidic tools in cell chemotaxis research. He is now collaborating with outstanding neurobiologists at the Massachusetts General Hospital to bring new technologies and better in vitro assays to the study of Alzheimer’s Disease and its underlying cellular and molecular mechanisms.

Related Research:

Exploring Sex Differences in AD Pathogenesis Using 3-D Human Non-Cell-Autonomous Models Doo Yeon Kim Daniel Irimia 2018-08-27

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Exploring Sex Differences in AD Pathogenesis Using 3-D Human Non-Cell-Autonomous Models 2017

$200,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kim, J. J., Hebisch, M., Kwak, S. S., Zheng, M., Nuli, S., Bae, J. S., Brand, E., Tanzi, R. E., Irimia, D., & Kim, D. Y. Cryopreserving 3D cell culture models of Alzheimer’s disease in hydrogel microbeads, Scientific Reports, April 12, 2025, Read More

Jorfi, M., D'Avanzo, C., Kim, D. Y., & Irimia, D. Three-Dimensional Models of the Human Brain Development and Disease, Advanced Healthcare Materials, August 28, 2017, Read More

Jorfi, M., Park, J., Hall, C. K., Lin, C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model, Nature Neuroscience, August 24, 2023, Read More

Kim, J. J., Jorfi, M., Tanzi, R. E., Kim, D. Y., Doyle, P. S., & Irimia, D. Patterning of interconnected human brain spheroids, Lab on a Chip, September 14, 2021, Read More

Jorfi, M., D'Avanzo, C., Tanzi, R. E., Kim, D. Y., & Irimia, D. Human Neurospheroid Arrays for in vitro studies of Alzheimer’s disease, Scientific Reports, February 5, 2018, Read More

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