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Eva-Maria Mandelkow, M.D., Ph.D.

Senior Group Leader, German Center for Neurodegenerative Diseases (DZNE), Germany

Eva-Maria Mandelkow studied medicine in Heidelberg and Hamburg, followed by a 3-year internship at university hospitals in Hamburg and Heidelberg, and then a doctoral dissertation at the Max Planck Institute for Medical Research, Heidelberg, with research on enzyme kinetics of the motor protein myosin. She then performed postdoctoral research at Brandeis University in Waltham, MA and at the Scripps Research Institute in La Jolla, CA. She joined the Max Planck Institute in Heidelberg as research scientist where she studied the self-assembly of microtubules by cryo-electron microscopy. After that she became Principal Investigator at the Max Planck Unit for Structural Molecular Biology at Deutsches Elektronen-Synchrotron (DESY), Hamburg. The current research interests of her group include the cell biology of tau protein and its role in Alzheimer’s disease, with emphasis on cell models, transgenic mouse models, and development of therapeutic approaches. She is recipient of a 2007 Breuer Award, a 2010 Metlife Award and a 2011 Potamkin Award. In 2011, she moved to the German Center for Neurodegenerative Diseases in Bonn (DZNE) as a Principal Investigator.

Related Research:

Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist Eva-Maria Mandelkow Anja Schneider Eckhard Mandelkow 2018-12-18 Tau Missorting in AD—Causes and Consequences Eckhard Mandelkow Eva-Maria Mandelkow 2016-01-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist 2018, 2020

$575,000
Tau Missorting in AD—Causes and Consequences 2015, 2017

$322,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Rodrigues, S., Anglada-Huguet, M., Hochgräfe, K., Kaniyappan, S., Wegmann, S., & Mandelkow, E. M. Spreading of Tau Protein Does Not Depend on Aggregation Propensity, Journal of Molecular Neuroscience, August 22, 2023, Read More

Wischhof, L., Adhikari, A., Mondal, M., Marsal-Cots, A., Biernat, J., Mandelkow, E. M., Mandelkow, E., Ehninger, D., Nicotera, P., & Bano, D. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau, Journal of Biological Chemistry, February 24, 2022, Read More

Wang, Y., Balaji, V., Kaniyappan, S., Krüger, L., Irsen, S., Tepper, K., Chandupatla, R., Maetzler, W., Schneider, A., Mandelkow, E., & Mandelkow, E. M. The release and trans-synaptic transmission of Tau via exosomes, Molecular Neurodegeneration, January 13, 2017, Read More

Kaniyappan, S., Tepper, K., Biernat, J., Chandupatla, R. R., Hübschmann, S., Irsen, S., Bicher, S., Klatt, C., Mandelkow, E. M., & Mandelkow, E. FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, Molecular Neurodegeneration, July 16, 2020, Read More

Anglada-Huguet, M., Rodrigues, S., Hochgräfe, K., Mandelkow, E., & Mandelkow, E. M. Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice, Alzheimer's & Dementia, April 19, 2021, Read More

Balaji, V., Kaniyappan, S., Mandelkow, E., Wang, Y., & Mandelkow, E. M. Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems, Autophagy, September 1, 2018, Read More

Endepols, H., Anglada-Huguet, M., Mandelkow, E., Neumaier, B., Mandelkow, E. M., & Drzezga, A. Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET, Experimental Neurology, December 3, 2023, Read More

Anglada-Huguet, M., Endepols, H., Sydow, A., Hilgers, R., Neumaier, B., Drzezga, A., Kaniyappan, S., Mandelkow, E., & Mandelkow, E. M. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy, International Journal of Molecular Sciences, May 25, 2023, Read More

Endepols, H., Anglada-Huguet, M., Mandelkow, E., Schmidt, Y., Krapf, P., Zlatopolskiy, B. D., Neumaier, B., Mandelkow, E. M., & Drzezga, A. Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study, Molecular Neurodegeneration, March 21, 2022, Read More

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