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Evandro F. Fang, Ph.D.

Associate Professor, Molecular Gerontology, University of Oslo, Akershus University Hospital, Norway

Evandro F. Fang is an Associate Professor of Molecular Gerontology at the University of Oslo (UiO), Norway, and his group is working on the molecular mechanisms of human aging and age-predisposed neurodegeneration (https://evandrofanglab.com/). More specifically, the Fang laboratory focuses on the molecular mechanisms behind how cells clear their damaged and aged mitochondria, a process termed “mitophagy,” as well as the roles of the NAD+-mitophagy/autophagy axis in healthy aging and AD inhibition. NAD+ is a fundamental molecule in life and health and decreases in ageing and AD. Dr Fang is fascinated with and actively engaged in moving his laboratory findings to translational applications and is involved in 5+ NAD+-based clinical trials, with the overarching goal of establishing novel and safe biological approaches to promote longer and healthier human lives.

After finishing his Ph.D. at the Chinese University of Hong Kong, he completed a 6-year postdoc training course on molecular gerontology with Prof. Vilhelm Bohr at the National Institute on Ageing, Baltimore. He opened his lab in Oslo in the fall of 2017. He has published over 100 papers in international peer-reviewed journals, including papers in Cell, Cell Metabolism, Nature Reviews MCB, Nature Neuroscience, Nature Ageing, and Nature Biomedical Engineering. He has received several awards, including the Butler-Williams Scholar on Aging 2016 by NIA (USA) and the ‘Scientific Award to Young Scientist in the Natural Sciences for 2020 by The Royal Norwegian Society of Sciences and Letters (Norway). He is the founding (co)coordinator of the Norwegian Centre on Healthy Ageing network (NO-Age, www.noage100.com), the Norwegian National anti-Alzheimer’s Disease Network (NO-AD, www.noad100.com), and the Hong Kong-Nordic Research Network.

To learn more, visit the Fang lab website or follow on X (@TheFangGroupUiO), Facebook, or LinkedIn.

Related Research:

Elucidating Mechanisms Driving the Compromised Balance Between Mitophagy and cGAS-STING-Initiated Inflammation Towards a Treatment for Alzheimer’s Disease Per Nilsson Evandro F. Fang 2024-08-22 Turning Up Mitophagy to Blunt Alzheimer’s Tau Pathologies Evandro F. Fang 2022-11-21

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Elucidating Mechanisms Driving the Compromised Balance Between Mitophagy and cGAS-STING-Initiated Inflammation Towards a Treatment for Alzheimer’s Disease 2024

$198,490
Turning Up Mitophagy to Blunt Alzheimer’s Tau Pathologies 2022, 2024

$401,925

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Wang, H. L., Zhang, J., Cao, S. Q., Lagartos-Donate, M. J., Zhang, S. Q., Lautrup, S., Hu, Z., Lyssiotis, C. A., Houtkooper, R. H., & Fang, E. F. A luminescent-based protocol for NAD+/NADH detection in C. elegans, mice, and human whole blood, STAR Protocols, November 1, 2024, Read More

Knapskog, A. B., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I., Watne, L. O., & Aksnes, M. Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease, Alzheimer's Research & Therapy, July 27, 2024, Read More

Omholt, S. W., Lejneva, R., Donate, M. J. L., Caponio, D., Fang, E. F., & Kobro-Flatmoen, A. Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons, Brain Structure & Function, June 25, 2024, Read More

Aittokallio, T., & Fang, E. F. Editorial overview-Artificial intelligence methodologies in structural biology: Bridging the gap to medical applications, Current Opinion in Structural Biology, June 12, 2024, Read More

Zhang, J., Wang, H. L., Veverová, K., Vyhnálek, M., & Fang, E. F. Identification and potential clinical applications of novel autophagy/mitophagy proteins in the biofluids of Alzheimer’s disease patients, Ageing Research Reviews, June 12, 2024, Read More

Veverová, K., Laczó, J., Katonová, A., Horáková, H., Matušková, V., Angelucci, F., Laczó, M., Nedelská, Z., Hort, J., Wang, H. L., Zhang, J., Shi, L., Fei Fang, E., & Vyhnálek, M. Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease, Autophagy, May 2, 2024, Read More

Wang, H. L., & Fang, E. F. PFASs May Risk Alzheimer’s Disease, The Journals of Gerontology. Series A, February 13, 2024, Read More

Pun, F. W., Leung, G. H. D., Leung, H. W., Rice, J., Schmauck-Medina, T., Lautrup, S., Long, X., Liu, B. H. M., Wong, C. W., Ozerov, I. V., Aliper, A., Ren, F., Rosenberg, A. J., Agrawal, N., Izumchenko, E., Fang, E. F., & Zhavoronkov, A. A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging, Aging Cell, October 27, 2023, Read More

Knapskog, A. B., Aksnes, M., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Saltvedt, I., Giil, L. M., & Watne, L. O. Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer’s disease, Alzheimer's & Dementia, June 2, 2023, Read More

Fang, E. F., Tavernarakis, N., & Palikaras, K. Editorial: Mitophagy in health and disease, volume II, Frontiers in Cell and Developmental Biology, June 29, 2023, Read More

Dong, Y., Zhuang, X. X., Wang, Y. T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H. M., Fang, E. F., & Lu, J. H. Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms, Pharmacological Research, June 20, 2023, Read More

Wang, H. L., Siow, R., Schmauck-Medina, T., … Fang, E. F. Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies, The Journals of Gerontology. Series A, January 30, 2024, Read More

Hong, Y., Zhang, Z., Yangzom, T., Chen, A., Lundberg, B. C., Fang, E. F., Siller, R., Sullivan, G. J., Zeman, J., Tzoulis, C., Bindoff, L. A., & Liang, K. X. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease, International Journal of Biological Sciences, January 25, 2024, Read More

Lautrup, S., Hou, Y., Fang, E. F., & Bohr, V. A. Roles of NAD+ in Health and Aging, Cold Spring Harbor Perspectives in Medicine, January 2, 2024, Read More

Fu, L., Tian, T., Wang, B., Lu, Z., Bian, J., Zhang, W., Wu, X., Li, X., Siow, R. C., Fang, E. F., He, N., & Zou, H. Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019, The Lancet. Healthy Longevity, January 1, 2024, Read More

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