These projects were made possible from Cure Alzheimer's Fund support.
|In Vivo Characterization of a Loss-of-Function GGA3 Rare Variant Associated with Alzheimer’s Disease||
|Functional Characterization of GGA3 Mutations Associated with Alzheimer’s Disease||
2015, 2017, 2018
|Understand the Role of ADAM10 in the Pathogenesis of Alzheimer’s Disease After Head Trauma||
|TBI and Stroke Relationship to Alzheimer’s Disease||
These published papers resulted from Cure Alzheimer’s Fund support.
David Cantu, Kendall Walker, Lauren Andresen, Amaro Taylor-Weiner, David Hampton, Giuseppina Tesco and Chris G. Dulla Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control, Cereb. Cortex, March 7, 2014, Read More
Walker KR, Tesco G Molecular mechanisms of cognitive dysfunction following traumatic brain injury, Front Aging Neurosci, 5(29), July 9, 2013, Read More
Kendall R. Walker, Eugene L. Kang, Michael J. Whalen, Yong Shen, and Giuseppina Tesco Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1, The Journal of Neuroscience, 32 (30), July 25, 2012, 10423–10437, Read More
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism, 31, January 2011, 351–61, Read More
Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F. Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy, Circulation: Journal of the American Heart Association, 121(10), Mar 16, 2010, 1216-26, Read More
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity., Human Molecular Genetics, Vol 18, Oct 15, 2009, Read More
Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity, Neuron, 54(5), 06/07/2007, 721-37, Read More